Vaccine elicited Fab C968.180 with influenza H10 JD13 HA trimer
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 9bu6
Q-score: 0.489
Mantus GE, Chopde AJ, Gorman J, Cominsky LY, Ourahmane A, Creanga A, Shimberg GD, Gillespie RA, Van Wazer DJ, Zhou T, Gajjala SR, Williams C, Maestle E, Reed DS, Serebryannyy L, Costner P, Holman L, Casazza JP, Koup RA, Dropulic LK, Kwong PD, McDermott AB, Kanekiyo M, Andrews SF
Sci Transl Med (2025) 17 pp. eadr8373-eadr8373 [ Pubmed: 39742506 DOI: doi:10.1126/scitranslmed.adr8373 ]
- Vaccine elicited fab c968.180 with influenza h10 jd13 ha trimer (Complex from Influenza A virus)
- Fab c968.180 heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab c968.180 light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 (35 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 (26 kDa, Protein from Influenza A virus)
Vaccine elicited Fab c115.131 with influenza H10 JD13 HA trimer
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 9bu8
Q-score: 0.414
Mantus GE, Chopde AJ, Gorman J, Cominsky LY, Ourahmane A, Creanga A, Shimberg GD, Gillespie RA, Van Wazer DJ, Zhou T, Gajjala SR, Williams C, Maestle E, Reed DS, Serebryannyy L, Costner P, Holman L, Casazza JP, Koup RA, Dropulic LK, Kwong PD, McDermott AB, Kanekiyo M, Andrews SF
Sci Transl Med (2025) 17 pp. eadr8373-eadr8373 [ Pubmed: 39742506 DOI: doi:10.1126/scitranslmed.adr8373 ]
- Fab c115.131 light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vaccine elicited fab c115.131 with influenza h10 jd13 ha trimer (Complex from Influenza A virus)
- Hemagglutinin ha1 (35 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 (26 kDa, Protein from Influenza A virus)
- Fab c115.131 heavy chain (13 kDa, Protein from Homo sapiens)
BG505 GT1.1 SOSIP in complex with NHP Fabs 12C11 and RM20A3
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sw3
Q-score: 0.564
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 12c11 heavy chain variable region (14 kDa, Protein from Macaca)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12c11 light chain variable region (11 kDa, Protein from Macaca)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip in complex with 12c11 fab and rm20a3 fab (720 kDa, Complex from Macaca)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8sw4
Q-score: 0.567
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- 21m20 heavy chain variable region (13 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gt1.1 sosip in complex with 21n13 fab, 21m20 fab and rm20a3 fab (770 kDa, Complex from Macaca)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 21m20 light chain variable region (11 kDa, Protein from Macaca)
- 21n13 light chain variable region (11 kDa, Protein from Macaca)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 21n13 heavy chain variable region (14 kDa, Protein from Macaca)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
Structure of influenza hemagglutinin from A/New Caledonia/20/99 in complex with FAB 441D6.
Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS
Nat Immunol (2019) 20 pp. 362-372 [ Pubmed: 30742080 DOI: doi:10.1038/s41590-018-0305-x ]
Electron cryo-microscopy of EBV gp350-based ferritin nanoparticle
Kanekiyo M, Bu W, Joyce MG, Meng G, Whittle JRR, Baxa U, Yamamoto T, Narpala S, Todd J-P, Rao SS, McDermott AB, Koup RA, Rossmann MG, Mascola JR, Graham BS, Cohen JI, Nabel GJ
Cell (2015) 162 pp. 1090-1100 [ Pubmed: 26279189 DOI: doi:10.1016/j.cell.2015.07.043 ]
Electron cryo-microscopy EBV gp350-based encapsulin nanoparticle
Kanekiyo M, Bu W, Joyce MG, Meng G, Whittle JR, Baxa U, Yamamoto T, Narpala S, Todd JP, Rao SS, McDermott AB, Koup RA, Rossmann MG, Mascola JR, Graham BS, Cohen JI, Nabel GJ
Cell (2015) 162 pp. 1090-1100 [ Pubmed: 26279189 DOI: doi:10.1016/j.cell.2015.07.043 ]