Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8gat
Q-score: 0.562
Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M
Immunity (2024) 57 pp. 574-586.e7 [ DOI: doi:10.1016/j.immuni.2024.02.003 Pubmed: 38430907 ]
- Fab 1g01, light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Influenza virus neuraminidase from a/indiana/10/2011 (h3n2v) in complex with fabs nds.1 and 1g01 (580 kDa, Complex from Homo sapiens)
- Fab 1g01, heavy chain (25 kDa, Protein from Homo sapiens)
- Vasodilator-stimulated phosphoprotein, neuraminidase chimera (51 kDa, Protein from Influenza A virus (A/Indiana/10/2011(H3N2)))
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8gau
Q-score: 0.449
Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M
Immunity (2024) 57 pp. 574-586.e7 [ DOI: doi:10.1016/j.immuni.2024.02.003 Pubmed: 38430907 ]
- Fab 1g01, light chain (23 kDa, Protein from Homo sapiens)
- Fab nds.1, heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Influenza virus neuraminidase from a/indiana/10/2011 (h3n2v) in complex with fabs nds.1 and 1g01 (580 kDa, Complex from Homo sapiens)
- Fab 1g01, heavy chain (25 kDa, Protein from Homo sapiens)
- Fab nds.1, light chain (23 kDa, Protein from Homo sapiens)
- Vasodilator-stimulated phosphoprotein, neuraminidase chimera (51 kDa, Protein from Influenza A virus (A/Indiana/10/2011(H3N2)))
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8gav
Q-score: 0.605
Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M
Immunity (2024) 57 pp. 574-586.e7 [ DOI: doi:10.1016/j.immuni.2024.02.003 Pubmed: 38430907 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Influenza virus neuraminidase from a/darwin/09/2021 (h3n2) in complex with fab nds.3 (380 kDa, Complex from Homo sapiens)
- Fab nds.3, heavy chain (24 kDa, Protein from Homo sapiens)
- Fab nds.3, light chain (22 kDa, Protein from Homo sapiens)
- Neuraminidase (51 kDa, Protein from Influenza A virus)
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8d21
Q-score: 0.395
Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA, Gorman J, Raab JE, Brand J, Creanga A, Gajjala SR, Narpala S, Cheung CSF, Harris DR, Zhou T, Gordon I, Holman L, Mendoza F, Houser KV, Chen GL, Mascola JR, Graham BS, Kwong PD, Widge A, Dropulic LK, Ledgerwood JE, Kanekiyo M, McDermott AB
Sci Transl Med (2023) 15 pp. eade4976-eade4976 [ DOI: doi:10.1126/scitranslmed.ade4976 Pubmed: 37075126 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1b06 light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em structure of the vrc321 clinical trial, vaccine-elicited, human antibody 1b06 in complex with a stabilized nc99 ha trimer (Complex)
- 1b06 fab with nc99 ha trimer (Complex from Influenza A virus)
- 1b06 heavy chain (13 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7tb8
Q-score: 0.41
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- The light chain of sars-cov-2 antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- The heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of sars-cov-2 antiboddy antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
Resolution: 5.08 Å
EM Method: Single-particle
Fitted PDBs: 7tc9
Q-score: 0.221
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibody a19-46.1, local refinement. (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7tca
Q-score: 0.282
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibody a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7tcc
Q-score: 0.268
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Light chain of antibody a19-46.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
- Heavy chain of antibody a19-46.1 (14 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7u0d
Q-score: 0.236
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of sars-cov-2 omicron rbd in complex with antibodies b1-182.1 and a19-46.1 (Complex from Homo sapiens)
- Heavy chain of sars-cov-2 antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Surface glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
- Light chain of sars-cov-2 antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of the spike of SARS-CoV-2 Omicron variant of concern
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7tb4
Q-score: 0.406
Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloninyi OK, Ransier A, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Cale EM, Chang LA, Corbett KS, DiPiazza AT, Gordon IJ, Leung K, Liu T, Mason RD, Nazzari A, Novik L, Olia AS, Doria-Rose NA, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner D, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
bioRxiv (2021) [ Pubmed: 33655252 DOI: doi:10.1101/2021.02.25.432969 ]