Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7l56
Q-score: 0.475
Rapp M, Guo Y, Reddem ER, Yu J, Liu L, Wang P, Cerutti G, Katsamba P, Bimela JS, Bahna FA, Mannepalli SM, Zhang B, Kwong PD, Huang Y, Ho DD, Shapiro L, Sheng Z
Cell Rep (2021) 35 pp. 108950-108950 [ Pubmed: 33794145 DOI: doi:10.1016/j.celrep.2021.108950 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab 2-43 variable domain heavy chain (14 kDa, Protein from Homo sapiens)
- Cryo-em structure of the sars-cov-2 spike glycoprotein bound to fab 2-43 (Complex from Homo sapiens)
- Fab 2-43 variable domain light chain (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-15
Resolution: 5.87 Å
EM Method: Single-particle
Fitted PDBs: 7l57
Q-score: 0.311
Rapp M, Guo Y, Reddem ER, Yu J, Liu L, Wang P, Cerutti G, Katsamba P, Bimela JS, Bahna FA, Mannepalli SM, Zhang B, Kwong PD, Huang Y, Ho DD, Shapiro L, Sheng Z
Cell Rep (2021) 35 pp. 108950-108950 [ Pubmed: 33794145 DOI: doi:10.1016/j.celrep.2021.108950 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 2-15 variable domain light chain (11 kDa, Protein from Homo sapiens)
- Fab 2-15 variable domain heavy chain (14 kDa, Protein from Homo sapiens)
- Cryo-em structure of the sars-cov-2 spike glycoprotein bound to fab 2-15 (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab H4
Resolution: 5.07 Å
EM Method: Single-particle
Fitted PDBs: 7l58
Q-score: 0.331
Rapp M, Guo Y, Reddem ER, Yu J, Liu L, Wang P, Cerutti G, Katsamba P, Bimela JS, Bahna FA, Mannepalli SM, Zhang B, Kwong PD, Huang Y, Ho DD, Shapiro L, Sheng Z
Cell Rep (2021) 35 pp. 108950-108950 [ Pubmed: 33794145 DOI: doi:10.1016/j.celrep.2021.108950 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 trimeric spike glycoprotein bound to one copy of fab h4 (Complex from Homo sapiens)
- Fab h4 variable domain heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab h4 variable domain light chain (12 kDa, Protein from Homo sapiens)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7l2d
Q-score: 0.425
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 1-87 light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-87 heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 1-87 fab (Complex from Homo sapiens)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7l2e
Q-score: 0.505
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-18 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 4-18 fab (Complex from Homo sapiens)
- 4-18 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7l2f
Q-score: 0.332
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 5-24 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-24 heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 5-24 fab (Complex from Homo sapiens)
Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7lqv
Q-score: 0.318
Cerutti G, Guo Y, ZHou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) [ DOI: doi:10.1016/j.chom.2021.03.005 ]
- 4-8 fab in complex with sars-cov-2 s2p spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-8 heavy chain (13 kDa, Protein from Homo sapiens)
- 4-8 light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.47 Å
EM Method: Single-particle
Fitted PDBs: 7lqw
Q-score: 0.222
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819-833.e7 [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-17 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-17 fab in complex with sars-cov-2 s2p spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-17 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7ls9
Q-score: 0.429
Cerutti G, Rapp M, Guo Y, Bahna F, Bimela J, Reddem ER, Yu J, Wang P, Liu L, Huang Y, Ho DD, Kwong PD, Sheng Z, Shapiro L
Structure (2021) 29 pp. 655-663.e4 [ DOI: doi:10.1016/j.str.2021.05.014 Pubmed: 34111408 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-57 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 1-57 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 1-57 fab heavy chain (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-7
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 7lss
Q-score: 0.428
Cerutti G, Rapp M, Guo Y, Bahna F, Bimela J, Reddem ER, Yu J, Wang P, Liu L, Huang Y, Ho DD, Kwong PD, Sheng Z, Shapiro L
Structure (2021) 29 pp. 655-663.e4 [ DOI: doi:10.1016/j.str.2021.05.014 Pubmed: 34111408 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 2-7 variable heavy chain (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein in complex with fab 2-7 variable domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab 2-7 variable light chain (11 kDa, Protein from Homo sapiens)