Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9ber
Q-score: 0.327
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of the hiv-1 jr-fl idl env trimer in complex with pgt122 fab (Complex from Human immunodeficiency virus 1)
Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9bew
Q-score: 0.488
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- 3bnc117 light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 3bnc117 heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of the hiv-1 bg505 idl env trimer in complex with 3bnc117 and 10-1074 fabs (Complex from Human immunodeficiency virus 1)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 9bf6
Q-score: 0.241
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- Phosphate ion (94 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of the hiv-1 wito idl env trimer in complex with pgt122 fab (Complex from Human immunodeficiency virus 1)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 8dul
Q-score: 0.241
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein e1 (52 kDa, Protein from Western equine encephalitis virus)
- Antibody fab skt05 light chain (23 kDa, Protein from Macaca fascicularis)
- Antibody fab skt05 heavy chain (25 kDa, Protein from Macaca fascicularis)
- Western equine encephalitis virus trimer in complex with antibody fab skt05 (Complex from Western equine encephalitis virus)
- Spike glycoprotein e2 (45 kDa, Protein from Western equine encephalitis virus)
Resolution: 5.84 Å
EM Method: Single-particle
Fitted PDBs: 8dun
Q-score: 0.214
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein e1 (52 kDa, Protein from Western equine encephalitis virus)
- Antibody skw11 light chain (23 kDa, Protein from Macaca fascicularis)
- Antibody skw11 heavy chain (24 kDa, Protein from Macaca fascicularis)
- Western equine encephalitis virus trimer in complex with antibody fab skw11 (Complex from Western equine encephalitis virus)
- Spike glycoprotein e2 (45 kDa, Protein from Western equine encephalitis virus)
Cryo-EM local refinement of antibody SKV09 in complex with VEEV alphavirus spike glycoprotein
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 8deq
Q-score: 0.19
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Skv09 fab heavy chain (13 kDa, Protein from Macaca)
- Spike glycoprotein e1 (43 kDa, Protein from Venezuelan equine encephalitis virus)
- Skv09 fab light chain (11 kDa, Protein from Macaca)
- Cryo-em local refinement of antibody skv09 in complex with veev alphavirus spike glycoprotein (Complex from Venezuelan equine encephalitis virus)
Cryo-EM local refinement of antibody SKV16 in complex with VEEV alphavirus spike glycoprotein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8der
Q-score: 0.443
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- Spike glycoprotein e2 (38 kDa, Protein from Venezuelan equine encephalitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em local refinement of antibody skv16 in complex with veev alphavirus spike glycoprotein (Complex from Venezuelan equine encephalitis virus)
- Spike glycoprotein e1 (43 kDa, Protein from Venezuelan equine encephalitis virus)
- Skv16 fab light chain (11 kDa, Protein from Macaca)
- Skv16 fab heavy chain (13 kDa, Protein from Macaca)
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7n28
Q-score: 0.385
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ DOI: doi:10.1002/advs.202200063 Pubmed: 35319830 ]
- Phosphate ion (94 Da, Ligand)
- A complex of hiv-1 env with antibodies 3bnc117 and j033 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- J033 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- J033 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (19 kDa, Protein from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mxd
Q-score: 0.47
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ DOI: doi:10.1002/advs.202200063 Pubmed: 35319830 ]
- Phosphate ion (94 Da, Ligand)
- J038 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- J038 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- A complex of hiv-1 env with antibodies 3bnc117 and j038 (Complex from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7tb8
Q-score: 0.41
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- The light chain of sars-cov-2 antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- The heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of sars-cov-2 antiboddy antibody b1-182.1 (13 kDa, Protein from Homo sapiens)