Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 8t5c
Q-score: 0.301
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ Pubmed: 38177144 DOI: doi:10.1038/s41467-023-44534-y ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1 (22 kDa, Protein from Lassa virus Josiah)
- 8.11g heavy chain (13 kDa, Protein from Homo sapiens)
- Lassa gpc trimer in complex with fab 8.11g and nanobody d5 (Complex from Lassa virus Josiah)
- D5 nanobody (13 kDa, Protein from Camelus bactrianus)
- 8.11g light chain (12 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (22 kDa, Protein from Lassa virus Josiah)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f7t
Q-score: 0.351
Olia AS, Cheng C, Zhou T, Biju A, Harris DR, Changela A, Duan H, Ivleva VB, Kong WP, Ou L, Rawi R, Tsybovsky Y, Van Wazer DJ, Corrigan AR, Gonelli CA, Lee M, McKee K, Narpala S, O'Dell S, Parchment DK, Stancofski ED, Stephens T, Tan I, Teng IT, Wang S, Wei Q, Yang Y, Yang Z, Zhang B, Novak J, Renfrow MB, Doria-Rose NA, Koup RA, McDermott AB, Gall JG, Lei QP, Mascola JR, Kwong PD
iScience (2023) 26 pp. 107403-107403 [ Pubmed: 37554450 DOI: doi:10.1016/j.isci.2023.107403 ]
- Hiv-1 env gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 consensus c env trimer with glycan covered base (Complex from Human immunodeficiency virus 1)
- Hiv-1 env gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8ek1
Q-score: 0.473
Tripathi P, Bender MF, Lei H, Da Silva Pereira L, Shen CH, Bonilla B, Dillon M, Ou L, Pancera M, Wang LT, Zhang B, Batista FD, Idris AH, Seder RA, Kwong PD
Structure (2023) 31 pp. 480-491.e4 [ DOI: doi:10.1016/j.str.2023.02.009 Pubmed: 36931276 ]
- L9 fab light chain (23 kDa, Protein from Homo sapiens)
- L9 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Circumsporozoite protein (37 kDa, Protein from Plasmodium falciparum 3D7)
- Pfcsp in complex with antibody l9 (Complex from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8eka
Q-score: 0.486
Tripathi P, Bender MF, Lei H, Da Silva Pereira L, Shen CH, Bonilla B, Dillon M, Ou L, Pancera M, Wang LT, Zhang B, Batista FD, Idris AH, Seder RA, Kwong PD
Structure (2023) 31 pp. 480-491.e4 [ DOI: doi:10.1016/j.str.2023.02.009 Pubmed: 36931276 ]
- Circumsporozoite protein (37 kDa, Protein from Plasmodium falciparum 3D7)
- L9 fab heavy chain (24 kDa, Protein from Homo sapiens)
- L9 fab light chain (23 kDa, Protein from Homo sapiens)
- Pfcsp in complex with antibody l9 (Complex from Homo sapiens)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7u0d
Q-score: 0.236
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of sars-cov-2 omicron rbd in complex with antibodies b1-182.1 and a19-46.1 (Complex from Homo sapiens)
- Heavy chain of sars-cov-2 antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Surface glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
- Light chain of sars-cov-2 antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
Cryo-EM Structure of disulfide stabilized HMPV F v4-B
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 7lze
Q-score: 0.528
Stewart-Jones GBE, Gorman J, Ou L, Zhang B, Joyce MG, Yang L, Cheng C, Chuang GY, Foulds KE, Kong WP, Olia AS, Sastry M, Shen CH, Todd JP, Tsybovsky Y, Verardi R, Yang Y, Collins PL, Corti D, Lanzavecchia A, Scorpio DG, Mascola JR, Buchholz UJ, Kwong PD
PNAS (2021) 118 [ Pubmed: 34551978 DOI: doi:10.1073/pnas.2106196118 ]
- Hmpv f v4-b (Complex from Human metapneumovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (54 kDa, Protein from Human metapneumovirus)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7khf
Q-score: 0.496
Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton PD, Geiger R, Sallusto F, Kwong PD, Lanzavecchia A
Nature (2021) 592 pp. 639-643 [ DOI: doi:10.1038/s41586-021-03378-6 Pubmed: 33790470 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rifin (15 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Mdb1 fab in complex with rifin (Complex from Homo sapiens)
- Mdb1 fab heavy chain (46 kDa, Protein from Homo sapiens)
- Mdb1 fab light chain (22 kDa, Protein from Homo sapiens)
- Mdb1 fab (Complex from Homo sapiens)
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 7kmb
Q-score: 0.427
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ DOI: doi:10.1016/j.chom.2020.11.004 Pubmed: 33271067 ]
- Ace2-rbd ph 7.4 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
Cryo-EM structure of stabilized HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 6vrw
Q-score: 0.46
Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, Moore PL, Morris L, Shapiro L, Mascola JR, Kwong PD
Cell Rep (2020) 31 pp. 107488-107488 [ Pubmed: 32268107 DOI: doi:10.1016/j.celrep.2020.03.052 ]
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 env trimer cap256 su.wk34.80 sosip.rns2 (Complex from Human immunodeficiency virus 1)
Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6mjz
Q-score: 0.282
Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, Thomas PV, Yang Y, Foulds KE, Todd JP, Wei H, Salazar AM, Scorpio DG, Carragher B, Potter CS, Corti D, Mascola JR, Lanzavecchia A, Kwong PD
PNAS (2018) 115 pp. 12265-12270 [ DOI: doi:10.1073/pnas.1811980115 Pubmed: 30420505 ]
- Pia174 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Complex of hpiv3 env q162c-l168c, i213c-g230c, a463v, i474y in complex with antibody pia174 (Complex from Human respirovirus 3)
- Pia174 fab light chain (22 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0 (54 kDa, Protein from Human parainfluenza virus 3)