Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9ber
Q-score: 0.327
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of the hiv-1 jr-fl idl env trimer in complex with pgt122 fab (Complex from Human immunodeficiency virus 1)
Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 9bf6
Q-score: 0.241
Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P
Cell Rep (2024) 43 pp. 114518-114518 [ Pubmed: 39028623 DOI: doi:10.1016/j.celrep.2024.114518 ]
- Phosphate ion (94 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of the hiv-1 wito idl env trimer in complex with pgt122 fab (Complex from Human immunodeficiency virus 1)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 8t5c
Q-score: 0.301
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ Pubmed: 38177144 DOI: doi:10.1038/s41467-023-44534-y ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1 (22 kDa, Protein from Lassa virus Josiah)
- 8.11g heavy chain (13 kDa, Protein from Homo sapiens)
- Lassa gpc trimer in complex with fab 8.11g and nanobody d5 (Complex from Lassa virus Josiah)
- D5 nanobody (13 kDa, Protein from Camelus bactrianus)
- 8.11g light chain (12 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (22 kDa, Protein from Lassa virus Josiah)
Cryo-EM Structure of Western Equine Encephalitis Virus
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 8dec
Q-score: 0.152
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- Western equine encephalitis virus (Virus from Western equine encephalitis virus)
- Spike glycoprotein e2 (46 kDa, Protein from Western equine encephalitis virus)
- Capsid protein (29 kDa, Protein from Western equine encephalitis virus)
- Spike glycoprotein e1 (47 kDa, Protein from Western equine encephalitis virus)
Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW19 fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ded
Q-score: 0.363
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- Spike glycoprotein e2 (46 kDa, Protein from Western equine encephalitis virus)
- Skw19 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Skw19 fab light chain (23 kDa, Protein from Homo sapiens)
- Western equine encephalitis virus (Virus from Western equine encephalitis virus)
- Spike glycoprotein e1 (47 kDa, Protein from Western equine encephalitis virus)
Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8def
Q-score: 0.302
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- Skw24 fab light chain (22 kDa, Protein from Homo sapiens)
- Spike glycoprotein e2 (46 kDa, Protein from Western equine encephalitis virus)
- Skw24 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Western equine encephalitis virus (Virus from Western equine encephalitis virus)
- Spike glycoprotein e1 (47 kDa, Protein from Western equine encephalitis virus)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 8dul
Q-score: 0.241
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ DOI: doi:10.1016/j.cell.2023.05.019 Pubmed: 37295404 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein e1 (52 kDa, Protein from Western equine encephalitis virus)
- Antibody fab skt05 light chain (23 kDa, Protein from Macaca fascicularis)
- Antibody fab skt05 heavy chain (25 kDa, Protein from Macaca fascicularis)
- Western equine encephalitis virus trimer in complex with antibody fab skt05 (Complex from Western equine encephalitis virus)
- Spike glycoprotein e2 (45 kDa, Protein from Western equine encephalitis virus)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1)
Resolution: 4.66 Å
EM Method: Single-particle
Fitted PDBs: 8g9w
Q-score: 0.237
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2)
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 8g9x
Q-score: 0.253
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 3)
Resolution: 4.28 Å
EM Method: Single-particle
Fitted PDBs: 8g9y
Q-score: 0.291
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)