KDL bound, nucleotide-free MsbA in open, outward-facing conformation
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8tso
Q-score: 0.59
Zhang T, Lyu J, Yang B, Yun SD, Scott E, Zhao M, Laganowsky A
Nat Commun (2024) 15 pp. 5946-5946 [ Pubmed: 39009687 DOI: doi:10.1038/s41467-024-50350-9 ]
- Atp-binding transport protein msba (64 kDa, Protein from Escherichia coli)
- Pentaethylene glycol monodecyl ether (378 Da, Ligand)
- (2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-[(2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-5-[[(3~{r})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-3-oxidanyl-5-[[(3~{r})-3-oxidanyltetradecanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{r})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid (2 kDa, Ligand)
- E. coli msba incubated with atp for 6 hours (Complex from Escherichia coli)
Open, inward-facing MsbA structure (OIF1)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8tsp
Q-score: 0.381
Zhang T, Lyu J, Yang B, Yun SD, Scott E, Zhao M, Laganowsky A
Nat Commun (2024) 15 pp. 5946-5946 [ Pubmed: 39009687 DOI: doi:10.1038/s41467-024-50350-9 ]
Open, inward-facing MsbA structure (OIF2)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tsq
Q-score: 0.424
Zhang T, Lyu J, Yang B, Yun SD, Scott E, Zhao M, Laganowsky A
Nat Commun (2024) 15 pp. 5946-5946 [ Pubmed: 39009687 DOI: doi:10.1038/s41467-024-50350-9 ]
Open, inward-facing MsbA structure (OIF4)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8tsr
Q-score: 0.37
Zhang T, Lyu J, Yang B, Yun SD, Scott E, Zhao M, Laganowsky A
Nat Commun (2024) 15 pp. 5946-5946 [ Pubmed: 39009687 DOI: doi:10.1038/s41467-024-50350-9 ]
Open, inward-facing MsbA structure (OIF3)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8tss
Q-score: 0.392
Zhang T, Lyu J, Yang B, Yun SD, Scott E, Zhao M, Laganowsky A
Nat Commun (2024) 15 pp. 5946-5946 [ Pubmed: 39009687 DOI: doi:10.1038/s41467-024-50350-9 ]
Structure of the vanadate-trapped MsbA bound to KDL
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8dmm
Q-score: 0.45
Lyu J, Liu C, Zhang T, Schrecke S, Elam NP, Packianathan C, Hochberg GKA, Russell D, Zhao M, Laganowsky A
Nat Commun (2022) 13 pp. 7291-7291 [ Pubmed: 36435815 DOI: doi:10.1038/s41467-022-34905-2 ]
- Atp-binding transport protein msba (64 kDa, Protein from Escherichia coli)
- Adp orthovanadate (544 Da, Ligand)
- (2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-[(2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-5-[[(3~{r})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-3-oxidanyl-5-[[(3~{r})-3-oxidanyltetradecanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{r})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid (2 kDa, Ligand)
- Vanadate-trapped msba kdl and adp orthovanadate (aov) (Complex from Escherichia coli)
Structure of open, inward-facing MsbA from E. coli
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8dmo
Q-score: 0.307
Lyu J, Liu C, Zhang T, Schrecke S, Elam NP, Packianathan C, Hochberg GKA, Russell D, Zhao M, Laganowsky A
Nat Commun (2022) 13 pp. 7291-7291 [ Pubmed: 36435815 DOI: doi:10.1038/s41467-022-34905-2 ]
- Copper-bound msba (Complex from Escherichia coli)
- Atp-binding transport protein msba (64 kDa, Protein from Escherichia coli)
Single-particle cryoEM data of a ternary KRas(G13D)-SOS complex
Moghadamchargari Z, Shirzadeh M, Liu C, Schrecke S, Packianathan C, Russell DH, Zhao M, Laganowsky A
Proc Natl Acad Sci U S A (2021) 118 [ DOI: 10.1073/pnas.2022403118 Pubmed: 33723061 ]
Image sets:
Structure of a ternary KRas(G13D)-SOS complex
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7kfz
Q-score: 0.44
Moghadamchargari Z, Shirzadeh M, Liu C, Schrecke S, Packianathan C, Russell DH, Zhao M, Laganowsky A
PNAS (2021) 118 [ Pubmed: 33723061 DOI: doi:10.1073/pnas.2022403118 ]
- Magnesium ion (24 Da, Ligand)
- Son of sevenless homolog 1 (57 kDa, Protein from Homo sapiens)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- A ternary complex of kras(g13d) and soscat (96 kDa, Complex from Homo sapiens)