Aquaporin Z with ALFA tag and bound to nanobody
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 8uy6
Q-score: 0.68
Stover L, Bahramimoghaddam H, Wang L, Schrecke S, Yadav GP, Zhou M, Laganowsky A
J Struct Biol X (2024) 9 pp. 100097-100097 [ DOI: doi:10.1016/j.yjsbx.2024.100097 Pubmed: 38361954 ]
- Cardiolipin (1 kDa, Ligand)
- Aquaporin z with alfa tag bound to nanobody (161 kDa, Complex)
- Nanobody (Complex from Vicugna pacos)
- Aquaporin z (26 kDa, Protein from Escherichia coli)
- Anti-alfa nanobody (13 kDa, Protein from Vicugna pacos)
- Aquaporin z with alfa tag (Complex from Escherichia coli)
Pendrin in complex with chloride
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8sgw
Q-score: 0.556
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Pendrin in complex with iodide
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sh3
Q-score: 0.544
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Iodide ion (126 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Pendrin in complex with Niflumic acid
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8shc
Q-score: 0.536
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid (282 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Pendrin in complex with bicarbonate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8sie
Q-score: 0.574
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bicarbonate ion (61 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8uuk
Q-score: 0.567
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of SLC40/ferroportin in complex with Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6vyh
Q-score: 0.532
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Nat Commun (2020) 11 pp. 5686-5686 [ DOI: doi:10.1038/s41467-020-19458-6 Pubmed: 33173040 ]
- Water (18 Da, Ligand)
- Solute carrier family 40 protein (63 kDa, Protein from Carlito syrichta)
- 11f9 heavy-chain (25 kDa, Protein from Mus musculus)
- Cobalt (ii) ion (58 Da, Ligand)
- Cryo-em map of slc40/ferroportin in complex with fab (Complex from Carlito syrichta)
- 11f9 light-chain (23 kDa, Protein from Mus musculus)
Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6wik
Q-score: 0.384
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Nat Commun (2020) 11 pp. 5686-5686 [ DOI: doi:10.1038/s41467-020-19458-6 Pubmed: 33173040 ]
- Cryo-em map of slc40/ferroportin with fab in the presence of hepcidin (Complex from Carlito syrichta)
- 11f9 fab light-chain (23 kDa, Protein from Mus musculus)
- 11f9 fab heavy-chain (25 kDa, Protein from Mus musculus)
- Solute carrier family 40 protein (63 kDa, Protein from Carlito syrichta)
Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vp0
Q-score: 0.514
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M
Nature (2020) 581 pp. 329-332 [ DOI: doi:10.1038/s41586-020-2280-2 Pubmed: 32433610 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Diacylglycerol o-acyltransferase 1 (55 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human diacylglycerol acyltransferase 1 in complex with oleoyl-coa (Complex from Homo sapiens)