Aquaporin Z with ALFA tag and bound to nanobody
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 8uy6
Q-score: 0.68
Stover L, Bahramimoghaddam H, Wang L, Schrecke S, Yadav GP, Zhou M, Laganowsky A
J Struct Biol X (2024) 9 pp. 100097-100097 [ DOI: doi:10.1016/j.yjsbx.2024.100097 Pubmed: 38361954 ]
- Cardiolipin (1 kDa, Ligand)
- Aquaporin z with alfa tag bound to nanobody (161 kDa, Complex)
- Nanobody (Complex from Vicugna pacos)
- Aquaporin z (26 kDa, Protein from Escherichia coli)
- Anti-alfa nanobody (13 kDa, Protein from Vicugna pacos)
- Aquaporin z with alfa tag (Complex from Escherichia coli)
KDL bound, nucleotide-free MsbA in open, outward-facing conformation
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8tso
Q-score: 0.59
Zhang T, Lyu J, Yang B, Yun SD, Scott E, Zhao M, Laganowsky A
Nat Commun (2024) 15 pp. 5946-5946 [ Pubmed: 39009687 DOI: doi:10.1038/s41467-024-50350-9 ]
- Atp-binding transport protein msba (64 kDa, Protein from Escherichia coli)
- Pentaethylene glycol monodecyl ether (378 Da, Ligand)
- (2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-[(2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-5-[[(3~{r})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-3-oxidanyl-5-[[(3~{r})-3-oxidanyltetradecanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{r})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid (2 kDa, Ligand)
- E. coli msba incubated with atp for 6 hours (Complex from Escherichia coli)
Pendrin in complex with chloride
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8sgw
Q-score: 0.556
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Pendrin in complex with iodide
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sh3
Q-score: 0.544
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Iodide ion (126 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Pendrin in complex with Niflumic acid
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8shc
Q-score: 0.536
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid (282 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Pendrin in complex with bicarbonate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8sie
Q-score: 0.574
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bicarbonate ion (61 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Decyl-beta-d-maltopyranoside (482 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8uuk
Q-score: 0.567
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Nat Commun (2024) 15 pp. 346-346 [ Pubmed: 38184688 DOI: doi:10.1038/s41467-023-44612-1 ]
- Homodimer of pendrin (75 kDa, Cellular component from Sus scrofa)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pendrin (86 kDa, Protein from Sus scrofa)
- Cholesterol (386 Da, Ligand)
Structure of the vanadate-trapped MsbA bound to KDL
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8dmm
Q-score: 0.45
Lyu J, Liu C, Zhang T, Schrecke S, Elam NP, Packianathan C, Hochberg GKA, Russell D, Zhao M, Laganowsky A
Nat Commun (2022) 13 pp. 7291-7291 [ Pubmed: 36435815 DOI: doi:10.1038/s41467-022-34905-2 ]
- Atp-binding transport protein msba (64 kDa, Protein from Escherichia coli)
- Adp orthovanadate (544 Da, Ligand)
- (2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-[(2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-5-[[(3~{r})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-3-oxidanyl-5-[[(3~{r})-3-oxidanyltetradecanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{r})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid (2 kDa, Ligand)
- Vanadate-trapped msba kdl and adp orthovanadate (aov) (Complex from Escherichia coli)
Structure of a ternary KRas(G13D)-SOS complex
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7kfz
Q-score: 0.44
Moghadamchargari Z, Shirzadeh M, Liu C, Schrecke S, Packianathan C, Russell DH, Zhao M, Laganowsky A
PNAS (2021) 118 [ Pubmed: 33723061 DOI: doi:10.1073/pnas.2022403118 ]
- Magnesium ion (24 Da, Ligand)
- Son of sevenless homolog 1 (57 kDa, Protein from Homo sapiens)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- A ternary complex of kras(g13d) and soscat (96 kDa, Complex from Homo sapiens)
Cryo-EM structure of SLC40/ferroportin in complex with Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6vyh
Q-score: 0.532
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Nat Commun (2020) 11 pp. 5686-5686 [ DOI: doi:10.1038/s41467-020-19458-6 Pubmed: 33173040 ]
- Water (18 Da, Ligand)
- Solute carrier family 40 protein (63 kDa, Protein from Carlito syrichta)
- 11f9 heavy-chain (25 kDa, Protein from Mus musculus)
- Cobalt (ii) ion (58 Da, Ligand)
- Cryo-em map of slc40/ferroportin in complex with fab (Complex from Carlito syrichta)
- 11f9 light-chain (23 kDa, Protein from Mus musculus)