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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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author:"Lam WH" AND xref_links:"pfam" AND natural_source_ncbi_code:"559292"

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EMD-37345

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Yeast replisome in state IV

Release date: Dec. 20, 2023
Resolution: 7.39 Å
EM Method: Single-particle
Fitted PDBs: 8w7s
Q-score: 0.212

Xu Z, Feng J, Yu D, Huo Y, Ma X, Lam WH, Liu Z, Li XD, Ishibashi T, Dang S, Zhai Y

Nat Commun (2023) 14 pp. 5849-5849 [ Pubmed: 37730685 DOI: doi:10.1038/s41467-023-41506-0 ]

Sample:

Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf2 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (71-mer) (22 kDa, DNA from Saccharomyces cerevisiae)
Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna polymerase epsilon subunit b (78 kDa, Protein from Saccharomyces cerevisiae S288C)
Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
Replisome complex in state iv (1 MDa, Complex from Saccharomyces cerevisiae)

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EMD-37211

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Yeast replisome in state I

Release date: Dec. 6, 2023
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8kg6
Q-score: 0.437

Xu Z, Feng J, Yu D, Huo Y, Ma X, Lam WH, Liu Z, Li XD, Ishibashi T, Dang S, Zhai Y

Nat Commun (2023) 14 pp. 5849-5849 [ Pubmed: 37730685 DOI: doi:10.1038/s41467-023-41506-0 ]

Sample:

Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf2 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288C)
Adenosine-5'-diphosphate (427 Da, Ligand)
Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (71-mer) (22 kDa, DNA from Saccharomyces cerevisiae)
Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna polymerase epsilon subunit b (78 kDa, Protein from Saccharomyces cerevisiae S288C)
Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
Chromosome segregation in meiosis protein 3 (36 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
Replisome complex in state i (1 MDa, Complex from Saccharomyces cerevisiae)
Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Topoisomerase 1-associated factor 1 (141 kDa, Protein from Saccharomyces cerevisiae S288C)
Magnesium ion (24 Da, Ligand)
Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae S288C)
Zinc ion (65 Da, Ligand)
Dna polymerase epsilon catalytic subunit a (255 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (61-mer) (18 kDa, DNA from Saccharomyces cerevisiae)

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EMD-37213

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Yeast replisome in state II

Release date: Dec. 6, 2023
Resolution: 4.23 Å
EM Method: Single-particle
Fitted PDBs: 8kg8
Q-score: 0.246

Xu Z, Feng J, Yu D, Huo Y, Ma X, Lam WH, Liu Z, Li XD, Ishibashi T, Dang S, Zhai Y

Nat Commun (2023) 14 pp. 5849-5849 [ Pubmed: 37730685 DOI: doi:10.1038/s41467-023-41506-0 ]

Sample:

Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf2 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288C)
Adenosine-5'-diphosphate (427 Da, Ligand)
Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (71-mer) (22 kDa, DNA from Saccharomyces cerevisiae)
Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna polymerase epsilon subunit b (78 kDa, Protein from Saccharomyces cerevisiae S288C)
Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae S288C)
Zinc ion (65 Da, Ligand)
Dna polymerase epsilon catalytic subunit a (255 kDa, Protein from Saccharomyces cerevisiae S288C)
Replisome complex in state ii (1 MDa, Complex from Saccharomyces cerevisiae)
Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (61-mer) (18 kDa, DNA from Saccharomyces cerevisiae)

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EMD-37215

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Yeast replisome in state III

Release date: Dec. 6, 2023
Resolution: 4.52 Å
EM Method: Single-particle
Fitted PDBs: 8kg9
Q-score: 0.19

Xu Z, Feng J, Yu D, Huo Y, Ma X, Lam WH, Liu Z, Li XD, Ishibashi T, Dang S, Zhai Y

Nat Commun (2023) 14 pp. 5849-5849 [ Pubmed: 37730685 DOI: doi:10.1038/s41467-023-41506-0 ]

Sample:

Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf2 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
Adenosine-5'-diphosphate (427 Da, Ligand)
Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (70-mer) (22 kDa, DNA from Saccharomyces cerevisiae)
Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna polymerase epsilon subunit b (78 kDa, Protein from Saccharomyces cerevisiae S288C)
Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae S288C)
Zinc ion (65 Da, Ligand)
Dna polymerase epsilon catalytic subunit a (255 kDa, Protein from Saccharomyces cerevisiae S288C)
Replisome complex in state ii (1 MDa, Complex from Saccharomyces cerevisiae)
Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (61-mer) (18 kDa, DNA from Saccharomyces cerevisiae)
Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)

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EMD-37343

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Yeast replisome in state V

Release date: Dec. 6, 2023
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8w7m
Q-score: 0.267

Xu Z, Feng J, Yu D, Huo Y, Ma X, Lam WH, Liu Z, Li XD, Ishibashi T, Dang S, Zhai Y

Nat Commun (2023) 14 pp. 5849-5849 [ Pubmed: 37730685 DOI: doi:10.1038/s41467-023-41506-0 ]

Sample:

Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf2 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
Adenosine-5'-diphosphate (427 Da, Ligand)
Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna (71-mer) (22 kDa, DNA from Saccharomyces cerevisiae)
Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna polymerase epsilon subunit b (78 kDa, Protein from Saccharomyces cerevisiae S288C)
Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288C)
Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Replisome complex in state v (1 MDa, Complex from Saccharomyces cerevisiae)
Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae S288C)
Zinc ion (65 Da, Ligand)
Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)

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EMD-6941

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Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element

Release date: July 11, 2018
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 5zr1
Q-score: 0.547

Li N, Lam WH, Zhai Y, Cheng J, Cheng E, Zhao Y, Gao N, Tye BK

Nature (2018) 559 pp. 217-222 [ Pubmed: 29973722 DOI: doi:10.1038/s41586-018-0293-x ]

Sample:

Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
72bp-oring dna, acs305, t-rich (22 kDa, DNA from Saccharomyces cerevisiae)
Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Saccharomyces cerevisiae origin recognition complex bound to a 72-bp origin dna containing acs and b1 element (Complex from Saccharomyces cerevisiae)
72bp-oring dna, acs305, a-rich (22 kDa, DNA from Saccharomyces cerevisiae)
Magnesium ion (24 Da, Ligand)
Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Origin recognition complex subunit 1 (104 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))

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Sort by: Download

Showing 1 - 6 of 6. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [6]

Format:

Select the script type:

Shell (Unix-based) Batch (Windows-based)

Preview first 10

Field: