Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8vsu
Q-score: 0.575
Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA
J Struct Biol (2024) 216 pp. 108108-108108 [ Pubmed: 38944401 DOI: doi:10.1016/j.jsb.2024.108108 ]
- Isoform 3 of ste20-related kinase adapter protein alpha (47 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Serine/threonine-protein kinase stk11 (50 kDa, Protein from Homo sapiens)
- Calcium-binding protein 39 (41 kDa, Protein from Homo sapiens)
- Heterotrimeric complex of serine/threonine kinase lkb1 with psuedokinase strada and scaffolding mo25a (140 kDa, Complex from Homo sapiens)
Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
Unliganded human transthyretin in the canonical conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve2
Q-score: 0.485
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the compressed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve3
Q-score: 0.498
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the frayed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve4
Q-score: 0.477
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ve5
Q-score: 0.489
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- Transthyretin (57 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve6
Q-score: 0.447
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve0
Q-score: 0.529
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)