Cryo-EM structure of human DELE1 in oligomeric form
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8d9x
Q-score: 0.326
Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Luke Wiseman R, Lander GC
Nat Struct Mol Biol (2023) 30 pp. 1295-1302 [ DOI: doi:10.1038/s41594-023-01061-0 Pubmed: 37550454 ]
Yeast Lon (PIM1) with endogenous substrate
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sxo
Q-score: 0.471
Yang J, Song AS, Wiseman RL, Lander GC
J Biol Chem (2022) 298 pp. 101694-101694 [ Pubmed: 35143841 DOI: doi:10.1016/j.jbc.2022.101694 ]
- Cryo-em structure of yeast lon (pim1) in complex with endogenous substrate (Complex from Saccharomyces cerevisiae)
- Endogenous substrate (1 kDa, Protein from Escherichia coli)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Human mitochondrial LONP1 in complex with Bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7krz
Q-score: 0.572
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
- Human mitochondrial lonp1 in complex with bortezomib (462 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Endogenous co-purified substrate (1 kDa, Protein from Escherichia coli BL21(DE3))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (59 kDa, Protein from Homo sapiens)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
Substrate-free human mitochondrial LONP1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ksl
Q-score: 0.506
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
- Substrate-free human mitochondrial lonp1 (462 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (58 kDa, Protein from Homo sapiens)
Human mitochondrial LONP1 with endogenous substrate
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ksm
Q-score: 0.568
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (59 kDa, Protein from Homo sapiens)
- Unidentified endogenous substrate (1 kDa, Protein from Escherichia coli BL21(DE3))
- Human mitochondrial lonp1 with endogenous substrate (462 kDa, Complex from Homo sapiens)
Structure of the human TRPV3 channel in the apo conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6mho
Q-score: 0.446
Zubcevic L, Herzik Jr MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Nat Commun (2018) 9 pp. 4773-4773 [ Pubmed: 30429472 DOI: doi:10.1038/s41467-018-07117-w ]
Structure of the human TRPV3 channel in a putative sensitized conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6mhs
Q-score: 0.392
Zubcevic L, Herzik Jr MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Nat Commun (2018) 9 pp. 4773-4773 [ Pubmed: 30429472 DOI: doi:10.1038/s41467-018-07117-w ]
Structure of human TRPV3 in the presence of 2-APB in C4 symmetry
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6mhv
Q-score: 0.481
Zubcevic L, Herzik Jr MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Nat Commun (2018) 9 pp. 4773-4773 [ Pubmed: 30429472 DOI: doi:10.1038/s41467-018-07117-w ]
Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (1)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6mhw
Q-score: 0.391
Zubcevic L, Herzik Jr MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Nat Commun (2018) 9 pp. 4773-4773 [ Pubmed: 30429472 DOI: doi:10.1038/s41467-018-07117-w ]
Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (2)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6mhx
Q-score: 0.372
Zubcevic L, Herzik Jr MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Nat Commun (2018) 9 pp. 4773-4773 [ Pubmed: 30429472 DOI: doi:10.1038/s41467-018-07117-w ]