Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8t42
Q-score: 0.395
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024) 20 pp. 1493-1504 [ Pubmed: 38658656 DOI: doi:10.1038/s41589-024-01599-0 ]
- Magnesium ion (24 Da, Ligand)
- Tubulin polyglutamylase ttll6 (Complex from Mus musculus)
- Tubulin alpha-1b chain, tubulin betai chain (Complex from Homo sapiens)
- Tubulin polyglutamylase ttll6 (59 kDa, Protein from Mus musculus)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ttll6 bound to unmodified human microtubules (300 kDa, Complex)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
Human DNA polymerase theta helicase domain tetramer in the apo form
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9bh6
Q-score: 0.488
Zerio CJ, Bai Y, Sosa-Alvarado BA, Guzi T, Lander GC
To Be Published
- Human dna polymerase theta helicase domain (400 kDa, Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
Human DNA polymerase theta helicase domain dimer in the apo form
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9bh7
Q-score: 0.436
Zerio CJ, Bai Y, Sosa-Alvarado BA, Guzi T, Lander GC
To Be Published
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
- Human dna polymerase theta helicase domain (200 kDa, Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9bh8
Q-score: 0.401
Zerio CJ, Bai Y, Sosa-Alvarado BA, Guzi T, Lander GC
To Be Published
- Human dna polymerase theta helicase domain bound to stem-loop dna with microhomology in the 3' overhang (20 kDa, Complex from Homo sapiens)
- Human dna polymerase theta helicase domain (Complex from Homo sapiens)
- Stem-loop dna with microhomology in the 3' overhang (Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
- Stem-loop dna with microhomology in the 3' overhang (17 kDa, DNA from synthetic construct)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9bh9
Q-score: 0.422
Zerio CJ, Bai Y, Sosa-Alvarado BA, Guzi T, Lander GC
To Be Published
- Human dna polymerase theta helicase domain bound to stem-loop dna with microhomology in the 3' overhang (20 kDa, Complex from Homo sapiens)
- Human dna polymerase theta helicase domain (Complex from Homo sapiens)
- Stem-loop dna with microhomology in the 3' overhang (Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
- Stem-loop dna with microhomology in the 3' overhang (17 kDa, DNA from synthetic construct)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9bha
Q-score: 0.43
Zerio CJ, Bai Y, Sosa-Alvarado BA, Guzi T, Lander GC
To Be Published
- Human dna polymerase theta helicase domain bound to stem-loop dna with microhomology in the 3' overhang (20 kDa, Complex from Homo sapiens)
- Human dna polymerase theta helicase domain (Complex from Homo sapiens)
- Stem-loop dna with microhomology in the 3' overhang (Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
- Stem-loop dna with microhomology in the 3' overhang (17 kDa, DNA from synthetic construct)
Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7kx7
Q-score: 0.457
Anzelon TA, Chowdhury S, Hughes SM, Xiao Y, Lander GC, MacRae IJ
Nature (2021) 597 pp. 285-289 [ Pubmed: 34471284 DOI: doi:10.1038/s41586-021-03856-x ]
- Rna (5'-r(p*up*cp*up*cp*ap*gp*(omc))-3') (8 kDa, RNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Piwi-a (88 kDa, Protein from Ephydatia fluviatilis)
- Pirna (Complex from synthetic construct)
- Complex between efpiwi and pirna (83 kDa, Complex)
- Piwi-a (Complex from Ephydatia fluviatilis)
Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7kx9
Q-score: 0.461
Anzelon TA, Chowdhury S, Hughes SM, Xiao Y, Lander GC, MacRae IJ
Nature (2021) 597 pp. 285-289 [ Pubmed: 34471284 DOI: doi:10.1038/s41586-021-03856-x ]
- Magnesium ion (24 Da, Ligand)
- Pirna-target (Complex from synthetic construct)
- Rna (5'-r(p*up*gp*up*cp*cp*ap*ap*cp*up*cp*ap*ap*gp*ap*gp*a)-3') (5 kDa, RNA from synthetic construct)
- Rna (5'-r(p*up*cp*up*cp*up*up*gp*ap*gp*up*up*gp*gp*ap*cp*ap*ap*ap*up*gp*gp*cp*ap*(omg))-3') (7 kDa, RNA from synthetic construct)
- Piwi-a (88 kDa, Protein from Ephydatia fluviatilis)
- Efpiwi-pirna-target complex (94 kDa, Complex)
- Piwi-a (Complex from Ephydatia fluviatilis)
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6pkv
Q-score: 0.319
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun (2019) 10 pp. 3740-3740 [ Pubmed: 31431622 DOI: doi:10.1038/s41467-019-11733-5 ]
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6pkw
Q-score: 0.296
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun (2019) 10 pp. 3740-3740 [ Pubmed: 31431622 DOI: doi:10.1038/s41467-019-11733-5 ]