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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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author:"Lander GC" AND software_ft:"RELION" AND author_orcid:"0000-0002-2368-6944"

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EMD-22259

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Human 20S proteasome bound to an engineered 11S (PA26) activator

Release date: July 22, 2020
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6xmj
Q-score: 0.584

Opoku-Nsiah KA, de la Pena AH, Williams SK, Chopra N, Sali A, Lander GC, Gestwicki JE

Nat Commun (2022) 13 pp. 1226-1226 [ Pubmed: 35264557 DOI: doi:10.1038/s41467-022-28864-x ]

Sample:

Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-7 (23 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
Mutant pa26 (Complex from Trypanosoma brucei)
Pa26-bound proteasome (Complex)
Proteasome subunit alpha type-4 (28 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (25 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-1 (26 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (27 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Proteasome activator protein pa26 (24 kDa, Protein from Trypanosoma brucei)
Proteasome (Complex from Homo sapiens)

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EMD-9042

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Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state)

Release date: Oct. 17, 2018
Resolution: 4.43 Å
EM Method: Single-particle
Fitted PDBs: 6ef0
Q-score: 0.383

de la Pena AH, Goodall EA, Gates SN, Lander GC, Martin A

Science (2018) 362 [ DOI: doi:10.1126/science.aav0725 Pubmed: 30309908 ]

Sample:

Proteasome subunit alpha type-4 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Substrate (Complex from Homo sapiens)
Proteasome subunit alpha type-1 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome subunit rpt4 (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 6a (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Adenosine-5'-diphosphate (427 Da, Ligand)
Proteasome subunit alpha type-5 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Adenosine-5'-triphosphate (507 Da, Ligand)
Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 7 homolog (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Substrate-engaged 26s proteasome in the 1d* state (Complex)
Proteasome subunit alpha type-3 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 8 homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 6b homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Model substrate polypeptide (1 kDa, Protein from Homo sapiens)
Probable proteasome subunit alpha type-7 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 4 homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))

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EMD-9043

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Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)

Release date: Oct. 17, 2018
Resolution: 4.73 Å
EM Method: Single-particle
Fitted PDBs: 6ef1
Q-score: 0.371

de la Pena AH, Goodall EA, Gates SN, Lander GC, Martin A

Science (2018) 362 [ DOI: doi:10.1126/science.aav0725 Pubmed: 30309908 ]

Sample:

Probable proteasome subunit alpha type-7 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Substrate (Complex from Homo sapiens)
26s proteasome regulatory subunit 6a (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 6b homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-3 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Model substrate polypeptide (1 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
26s proteasome regulatory subunit 8 homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-1 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-5 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Adenosine-5'-triphosphate (507 Da, Ligand)
26s proteasome regulatory subunit 4 homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-4 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Substrate-engaged 26s proteasome in the 5d state (composite map) (Complex)
Proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome subunit rpt4 (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 7 homolog (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))

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EMD-9044

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Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state)

Release date: Oct. 17, 2018
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 6ef2
Q-score: 0.43

de la Pena AH, Goodall EA, Gates SN, Lander GC, Martin A

Science (2018) 362 [ DOI: doi:10.1126/science.aav0725 Pubmed: 30309908 ]

Sample:

Substrate (Complex from Homo sapiens)
Substrate-engaged 26s proteasome in the 5t state (Complex)
Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 8 homolog (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Adenosine-5'-diphosphate (427 Da, Ligand)
26s proteasome regulatory subunit 7 homolog (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Adenosine-5'-triphosphate (507 Da, Ligand)
Proteasome subunit alpha type-4 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 6b homolog (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 4 homolog (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-1 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-3 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome subunit rpt4 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Proteasome subunit alpha type-5 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Model substrate polypeptide (1 kDa, Protein from Homo sapiens)
Probable proteasome subunit alpha type-7 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26s proteasome regulatory subunit 6a (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))

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EMD-9045

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Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)

Release date: Oct. 17, 2018
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 6ef3
Q-score: 0.46

de la Pena AH, Goodall EA, Gates SN, Lander GC, Martin A

Science (2018) 362 [ DOI: doi:10.1126/science.aav0725 Pubmed: 30309908 ]

Sample:

Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
Substrate (Complex from Homo sapiens)
Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
26s proteasome regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae S288c)
Model substrate polypeptide (4 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae S288c)
26s proteasome regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae S288c)
Adenosine-5'-diphosphate (427 Da, Ligand)
Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288c)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
Adenosine-5'-triphosphate (507 Da, Ligand)
26s proteasome regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit beta type-7 (1 kDa, Protein from Saccharomyces cerevisiae S288c)
26s proteasome regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288c)
26s proteasome subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288c)
Substrate-engaged 26s proteasome in the 4d state (Complex)
Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288c)
Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288c)

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EMDB [5]

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