Human mitochondrial LONP1 in complex with Bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7krz
Q-score: 0.572
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
- Human mitochondrial lonp1 in complex with bortezomib (462 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Endogenous co-purified substrate (1 kDa, Protein from Escherichia coli BL21(DE3))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (59 kDa, Protein from Homo sapiens)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
WalkerB mutant human mitochondrial LONP1 bound to endogenous substrate
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
Substrate-free human mitochondrial LONP1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ksl
Q-score: 0.506
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
- Substrate-free human mitochondrial lonp1 (462 kDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (58 kDa, Protein from Homo sapiens)
Human mitochondrial LONP1 with endogenous substrate
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ksm
Q-score: 0.568
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC
Nat Commun (2021) 12 pp. 3239-3239 [ DOI: doi:10.1038/s41467-021-23495-0 Pubmed: 34050165 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lon protease homolog, mitochondrial (59 kDa, Protein from Homo sapiens)
- Unidentified endogenous substrate (1 kDa, Protein from Escherichia coli BL21(DE3))
- Human mitochondrial lonp1 with endogenous substrate (462 kDa, Complex from Homo sapiens)
Mitochondrial ATPase Protease YME1
Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC
Science (2017) 358 [ Pubmed: 29097521 DOI: doi:10.1126/science.aao0464 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Poly(unk) (869 Da, Protein from Escherichia coli)
- Yme1 atpase protease walker b mutant bound to substrate (295 kDa, Complex from Saccharomyces cerevisiae)
- Mitochondrial inner membrane i-aaa protease supercomplex subunit yme1 (48 kDa, Protein from Saccharomyces cerevisiae (strain RM11-1a))