Misson Mindrebo LE, Mindrebo JT, Tran Q, Wilkinson MC, Smith JM, Verma M, Casewell NR, Lander GC, Jardine JG
Toxins (2024) 16 [ DOI: doi:10.3390/toxins16080361 Pubmed: 39195771 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ecarin in complex with neutralizing antibody h11 (Complex from Echis pyramidum leakeyi)
- Endogenous peptide (613 Da, Protein from Homo sapiens)
- H11 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Zinc metalloproteinase-disintegrin-like ecarin (47 kDa, Protein from Echis carinatus)
- H11 fab light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 9c0c
Q-score: 0.486
Godek J, Sivinski J, Watson ER, Lebario F, Xu W, Stevens M, Zerio CJ, Ambrose AJ, Zhu X, Trindl CA, Zhang DD, Johnson SM, Lander GC, Chapman E
J Am Chem Soc (2024) 146 pp. 20845-20856 [ DOI: doi:10.1021/jacs.4c05057 Pubmed: 39041457 ]
- 60 kda chaperonin (57 kDa, Protein from Escherichia coli)
- E.coli groel apoenzyme (Complex from Escherichia coli)
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 9c0d
Q-score: 0.303
Godek J, Sivinski J, Watson ER, Lebario F, Xu W, Stevens M, Zerio CJ, Ambrose AJ, Zhu X, Trindl CA, Zhang DD, Johnson SM, Lander GC, Chapman E
J Am Chem Soc (2024) 146 pp. 20845-20856 [ DOI: doi:10.1021/jacs.4c05057 Pubmed: 39041457 ]
- Chaperonin groel (57 kDa, Protein from Enterococcus faecium)
- E.faecium groel (Complex from Enterococcus faecium)
Human Mitochondrial LONP1 Degrading Casein, ATP-bound closed form
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 9cc0
Q-score: 0.501
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.24.600538 Pubmed: 38979310 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Lon protease homolog, mitochondrial (97 kDa, Protein from Homo sapiens)
- Bound substrate segment undergoing translocation and subsequent degradation (1 kDa, Protein from Bos taurus)
- Lonp1 degrading casein (583 kDa, Complex from Homo sapiens)
Human Mitochondrial LONP1 Stall State + casein
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9cc3
Q-score: 0.489
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.24.600538 Pubmed: 38979310 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Lon protease homolog, mitochondrial (97 kDa, Protein from Homo sapiens)
- Endogenous co-purified substrate modeled as unknown residues (2 kDa, Protein from Escherichia coli 'BL21-Gold(DE3)pLysS AG')
- Lonp1 closed state in complex with casein (583 kDa, Complex from Homo sapiens)
Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8vsu
Q-score: 0.575
Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA
J Struct Biol (2024) 216 pp. 108108-108108 [ DOI: doi:10.1016/j.jsb.2024.108108 Pubmed: 38944401 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Serine/threonine-protein kinase stk11 (50 kDa, Protein from Homo sapiens)
- Heterotrimeric complex of serine/threonine kinase lkb1 with psuedokinase strada and scaffolding mo25a (140 kDa, Complex from Homo sapiens)
- Calcium-binding protein 39 (41 kDa, Protein from Homo sapiens)
- Isoform 3 of ste20-related kinase adapter protein alpha (47 kDa, Protein from Homo sapiens)
Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ Pubmed: 39843982 DOI: doi:10.1038/s41594-024-01472-7 ]
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
Unliganded human transthyretin in the canonical conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve2
Q-score: 0.485
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ Pubmed: 39843982 DOI: doi:10.1038/s41594-024-01472-7 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the compressed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve3
Q-score: 0.498
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ Pubmed: 39843982 DOI: doi:10.1038/s41594-024-01472-7 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the frayed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve4
Q-score: 0.477
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ Pubmed: 39843982 DOI: doi:10.1038/s41594-024-01472-7 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)