Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
Unliganded human transthyretin in the canonical conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve2
Q-score: 0.485
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the compressed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve3
Q-score: 0.498
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the frayed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve4
Q-score: 0.477
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ve5
Q-score: 0.489
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- Transthyretin (57 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve6
Q-score: 0.447
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve0
Q-score: 0.529
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
Cryo-EM structure of human DELE1 in oligomeric form
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8d9x
Q-score: 0.326
Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Luke Wiseman R, Lander GC
Nat Struct Mol Biol (2023) 30 pp. 1295-1302 [ DOI: doi:10.1038/s41594-023-01061-0 Pubmed: 37550454 ]