Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8vsu
Q-score: 0.575
Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA
J Struct Biol (2024) 216 pp. 108108-108108 [ Pubmed: 38944401 DOI: doi:10.1016/j.jsb.2024.108108 ]
- Isoform 3 of ste20-related kinase adapter protein alpha (47 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Serine/threonine-protein kinase stk11 (50 kDa, Protein from Homo sapiens)
- Calcium-binding protein 39 (41 kDa, Protein from Homo sapiens)
- Heterotrimeric complex of serine/threonine kinase lkb1 with psuedokinase strada and scaffolding mo25a (140 kDa, Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8t42
Q-score: 0.395
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024) 20 pp. 1493-1504 [ Pubmed: 38658656 DOI: doi:10.1038/s41589-024-01599-0 ]
- Magnesium ion (24 Da, Ligand)
- Tubulin polyglutamylase ttll6 (Complex from Mus musculus)
- Tubulin alpha-1b chain, tubulin betai chain (Complex from Homo sapiens)
- Tubulin polyglutamylase ttll6 (59 kDa, Protein from Mus musculus)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ttll6 bound to unmodified human microtubules (300 kDa, Complex)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
Compressed conformation of nighttime state KaiC
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7s65
Q-score: 0.49
Swan JA, Sandate CR, Chavan AG, Freeberg AM, Etwaru D, Ernst DC, Palacios JG, Golden SS, LiWang A, Lander GC, Partch CL
Nat Struct Mol Biol (2022) 29 pp. 759-766 [ DOI: doi:10.1038/s41594-022-00803-w Pubmed: 35864165 ]
- Circadian clock protein kinase kaic (58 kDa, Protein from Synechococcus elongatus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Compressed state hexamer of nighttime state phosphomutant kaic (kaic-ea) (350 kDa, Complex from Synechococcus elongatus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Extended conformation of nighttime state KaiC
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7s66
Q-score: 0.554
Swan JA, Sandate CR, Chavan AG, Freeberg AM, Etwaru D, Ernst DC, Palacios JG, Golden SS, LiWang A, Lander GC, Partch CL
Nat Struct Mol Biol (2022) 29 pp. 759-766 [ DOI: doi:10.1038/s41594-022-00803-w Pubmed: 35864165 ]
- Extended state hexamer of nighttime state phosphomutant kaic (kaic-ea) (350 kDa, Complex from Synechococcus elongatus)
- Circadian clock protein kinase kaic (58 kDa, Protein from Synechococcus elongatus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Extended conformation of daytime state KaiC
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7s67
Q-score: 0.408
Swan JA, Sandate CR, Chavan AG, Freeberg AM, Etwaru D, Ernst DC, Palacios JG, Golden SS, LiWang A, Lander GC, Partch CL
Nat Struct Mol Biol (2022) 29 pp. 759-766 [ DOI: doi:10.1038/s41594-022-00803-w Pubmed: 35864165 ]
- Circadian clock protein kinase kaic (58 kDa, Protein from Synechococcus elongatus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Compressed state hexamer of nighttime state phosphomutant kaic (kaic-ea) (350 kDa, Complex from Synechococcus elongatus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Cryo-electron microscopy structure of a TRPML3 ion channel
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 5w3s
Q-score: 0.491
Hirschi M, Herzik MA, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY
Nature (2017) 550 pp. 411-414 [ Pubmed: 29019979 DOI: doi:10.1038/nature24055 ]
- Mucolipin-3 isoform 1 (65 kDa, Protein from Callithrix jacchus)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Transient receptor potential mucolipin 3 (260 kDa, Complex from Callithrix jacchus)
- Sodium ion (22 Da, Ligand)