Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8vsu
Q-score: 0.575
Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA
J Struct Biol (2024) 216 pp. 108108-108108 [ Pubmed: 38944401 DOI: doi:10.1016/j.jsb.2024.108108 ]
- Isoform 3 of ste20-related kinase adapter protein alpha (47 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Serine/threonine-protein kinase stk11 (50 kDa, Protein from Homo sapiens)
- Calcium-binding protein 39 (41 kDa, Protein from Homo sapiens)
- Heterotrimeric complex of serine/threonine kinase lkb1 with psuedokinase strada and scaffolding mo25a (140 kDa, Complex from Homo sapiens)
Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ve5
Q-score: 0.489
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- Transthyretin (57 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve6
Q-score: 0.447
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01472-7 Pubmed: 39843982 ]
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
Single-particle cryo-EM reconstruction of rabbit muscle aldolase using 200 keV
J Struct Biol X (2020) 4 pp. 100020-100020 [ DOI: doi:10.1016/j.yjsbx.2020.100020 Pubmed: 32647824 ]
- Water (18 Da, Ligand)
- Aldolase from rabbit muscle (150 kDa, Complex from Oryctolagus cuniculus)
- Fructose-bisphosphate aldolase a (37 kDa, Protein from Oryctolagus cuniculus)
Single-particle cryo-EM reconstruction of mouse heavy chain apoferritin at 200 keV
J Struct Biol X (2020) 4 pp. 100020-100020 [ DOI: doi:10.1016/j.yjsbx.2020.100020 Pubmed: 32647824 ]
- Water (18 Da, Ligand)
- Heavy chain apoferritin from mouse (505 kDa, Complex from Mus musculus)
- Ferritin heavy chain (20 kDa, Protein from Mus musculus)
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6pkx
Q-score: 0.317
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun (2019) 10 pp. 3740-3740 [ Pubmed: 31431622 DOI: doi:10.1038/s41467-019-11733-5 ]
- [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2r,3s,4r,5s)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate (559 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 2 (Complex from Danio rerio)
- Transient receptor potential cation channel subfamily m member 2 (167 kDa, Protein from Danio rerio)
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6d73
Q-score: 0.365
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun (2019) 10 pp. 3740-3740 [ Pubmed: 31431622 DOI: doi:10.1038/s41467-019-11733-5 ]
Single-particle cryo-EM reconstruction of horse liver alcohol dehydrogenase using 200 keV
Nat Commun (2019) 10 pp. 1032-1032 [ Pubmed: 30833564 DOI: doi:10.1038/s41467-019-08991-8 ]
- Alcohol dehydrogenase from equine liver (81 kDa, Complex from Equus caballus)
- Zinc ion (65 Da, Ligand)
- Alcohol dehydrogenase e chain (39 kDa, Protein from Equus caballus)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
Cryo-EM structure of a mitochondrial calcium uniporter
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6dt0
Q-score: 0.402
Yoo J, Wu M, Yin Y, Herzik Jr MA, Lander GC, Lee SY
Science (2018) 361 pp. 506-511 [ DOI: doi:10.1126/science.aar4056 Pubmed: 29954988 ]
- Calcium ion (40 Da, Ligand)
- Mitochondrial calcium uniporter (52 kDa, Protein from Neurospora crassa)
- Mitochondrial calcium uniporter (Complex from Neurospora crassa)