Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8erq
Q-score: 0.493
Park YJ, Pinto D, Walls AC, Liu Z, De Marco A, Benigni F, Zatta F, Silacci-Fregni C, Bassi J, Sprouse KR, Addetia A, Bowen JE, Stewart C, Giurdanella M, Saliba C, Guarino B, Schmid MA, Franko NM, Logue JK, Dang HV, Hauser K, di Iulio J, Rivera W, Schnell G, Rajesh A, Zhou J, Farhat N, Kaiser H, Montiel-Ruiz M, Noack J, Lempp FA, Janer J, Abdelnabi R, Maes P, Ferrari P, Ceschi A, Giannini O, de Melo GD, Kergoat L, Bourhy H, Neyts J, Soriaga L, Purcell LA, Snell G, Whelan SPJ, Lanzavecchia A, Virgin HW, Piccoli L, Chu HY, Pizzuto MS, Corti D, Veesler D
Science (2022) 378 pp. 619-627 [ Pubmed: 36264829 DOI: doi:10.1126/science.adc9127 ]
- S2x324 fab heavy chain (13 kDa, Protein from Homo sapiens)
- S2x324 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 ba.1 spike ectodomain trimer in complex with the s2x324 neutralizing antibody fab fragment (local refinement of the rbd and s2x324) (Complex from Severe acute respiratory syndrome coronavirus 2)
- S2x324 fab (Complex from Homo sapiens)
- Sars-cov-2 omicron ba.1 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8err
Q-score: 0.449
Park YJ, Pinto D, Walls AC, Liu Z, De Marco A, Benigni F, Zatta F, Silacci-Fregni C, Bassi J, Sprouse KR, Addetia A, Bowen JE, Stewart C, Giurdanella M, Saliba C, Guarino B, Schmid MA, Franko NM, Logue JK, Dang HV, Hauser K, di Iulio J, Rivera W, Schnell G, Rajesh A, Zhou J, Farhat N, Kaiser H, Montiel-Ruiz M, Noack J, Lempp FA, Janer J, Abdelnabi R, Maes P, Ferrari P, Ceschi A, Giannini O, de Melo GD, Kergoat L, Bourhy H, Neyts J, Soriaga L, Purcell LA, Snell G, Whelan SPJ, Lanzavecchia A, Virgin HW, Piccoli L, Chu HY, Pizzuto MS, Corti D, Veesler D
Science (2022) 378 pp. 619-627 [ Pubmed: 36264829 DOI: doi:10.1126/science.adc9127 ]
- Sars-cov-2 omicron ba.1 spike ectodomain trimer in complex with the s2x324 neutralizing antibody fab fragment (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.1 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- S2x324 fab (Complex from Homo sapiens)
- S2x324 light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2x324 heavy chain (13 kDa, Protein from Homo sapiens)
MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nb3
Q-score: 0.402
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D
Cell (2019) 176 pp. 1026-1039.e15 [ Pubmed: 30712865 DOI: doi:10.1016/j.cell.2018.12.028 ]
- Mers-cov complex with human neutralizing lca60 antibody fab fragment (state 1) (572 MDa, Complex from Middle East respiratory syndrome coronavirus)
- Spike glycoprotein (149 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Lca60 light chain (11 kDa, Protein from Homo sapiens)
- Lca60 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6nb4
Q-score: 0.403
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D
Cell (2019) 176 pp. 1026-1039.e15 [ Pubmed: 30712865 DOI: doi:10.1016/j.cell.2018.12.028 ]
- Lca60 light chain (11 kDa, Protein from Homo sapiens)
- Mers-cov complex with human neutralizing lca60 antibody fab fragment (state 2) (570 kDa, Complex from Middle East respiratory syndrome coronavirus)
- Spike glycoprotein (149 kDa, Protein from Middle East respiratory syndrome coronavirus)
- Lca60 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 1)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6nb6
Q-score: 0.338
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D
Cell (2019) 176 pp. 1026-1039.e15 [ Pubmed: 30712865 DOI: doi:10.1016/j.cell.2018.12.028 ]
- S230 light chain (12 kDa, Protein from Homo sapiens)
- Sars-cov s complex with human neutralizing s230 antibody fab fragment (state 1) (572 MDa, Complex from SARS coronavirus)
- Spike glycoprotein (139 kDa, Protein from SARS coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S230 heavy chain (14 kDa, Protein from Homo sapiens)
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6nb7
Q-score: 0.265
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D
Cell (2019) 176 pp. 1026-1039.e15 [ Pubmed: 30712865 DOI: doi:10.1016/j.cell.2018.12.028 ]
- S230 light chain (12 kDa, Protein from Homo sapiens)
- Sars-cov s complex with human neutralizing s230 antibody fab fragment (state 2) (572 MDa, Complex from SARS coronavirus)
- Spike glycoprotein (139 kDa, Protein from SARS coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S230 heavy chain (14 kDa, Protein from Homo sapiens)