Rat TRPV2 WT bound to probenecid
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- Homotetramer of rat trpv2 wt (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
Rat TRPV2 WT in the presence of probenecid and 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
Rat TRPV2 E724A/D725A bound to 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
Rat TRPV2 E724A/D725A bound to probenecid
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
Rat TRPV2 E724A/D725A bound to probenecid and 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
Wildtype rat TRPV2 in nanodiscs bound to RR
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8ffl
Q-score: 0.533
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ DOI: doi:10.1038/s44319-023-00050-0 Pubmed: 38225355 ]
Wildtype rat TRPV2 in nanodiscs bound to RR and 2-APB
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ffm
Q-score: 0.606
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ DOI: doi:10.1038/s44319-023-00050-0 Pubmed: 38225355 ]
- Tetramer of wildtype rat trpv2 in nanodiscs bound to ruthenium red (340 kDa, Complex from Rattus norvegicus)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
RR-bound wildtype rabbit TRPV5 in nanodiscs
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8ffn
Q-score: 0.577
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ DOI: doi:10.1038/s44319-023-00050-0 Pubmed: 38225355 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- Tetramer of wildtype rabbit trpv5 in nanodiscs bound to ruthenium red (335 kDa, Complex from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)
Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8ffq
Q-score: 0.624
Pumroy RA, De Jesus-Perez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024) 25 pp. 506-523 [ DOI: doi:10.1038/s44319-023-00050-0 Pubmed: 38225355 ]
- Tetramer of wildtype rabbit trpv5 into nanodiscs in complex with ruthenium red and pi(4,5)p2 (335 kDa, Complex from Oryctolagus cuniculus)
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Ergosterol (396 Da, Ligand)
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)