Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 9dzu
Q-score: 0.479
Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Hu G, Yiu B, Chou S, Bian Z, Guo ABY, Sun S, Robbins N, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Cowen LE, Heitman J, Li H, Wright GD
bioRxiv (2025) [ Pubmed: 39829750 DOI: doi:10.1101/2025.01.06.630955 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3r,4r,5s)-3,4-dihydroxy-5-[(1r,2r,3s,4s,5r,6r,10e,14z,16e,18z)-1,2,3,4,5-pentahydroxy-6,20,20-trimethylhenicosa-10,14,16,18-tetraen-1-yl]oxolan-2-one (526 Da, Ligand)
- Transcription regulator (45 kDa, Protein from Cryptococcus neoformans var. grubii H99)
- Magnesium ion (24 Da, Ligand)
- Beryllium trifluoride ion (66 Da, Ligand)
- Phospholipid-transporting atpase (176 kDa, Protein from Cryptococcus neoformans var. grubii H99)
- Apt1-cdc50 heterodimer bound with butyrolactol a (222 kDa, Complex from Cryptococcus neoformans var. grubii H99)
Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 in the E1 state
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 9dzv
Q-score: 0.399
Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Hu G, Yiu B, Chou S, Bian Z, Guo ABY, Sun S, Robbins N, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Cowen LE, Heitman J, Li H, Wright GD
bioRxiv (2025) [ Pubmed: 39829750 DOI: doi:10.1101/2025.01.06.630955 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Apt1-cdc50 heterodimer (222 kDa, Complex from Cryptococcus neoformans var. grubii H99)
- Transcription regulator (45 kDa, Protein from Cryptococcus neoformans var. grubii H99)
- Magnesium ion (24 Da, Ligand)
- Phospholipid-transporting atpase (176 kDa, Protein from Cryptococcus neoformans var. grubii H99)
Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9js4
Q-score: 0.434
Liao Y, Ma H, Wang Z, Wang S, He Y, Chang Y, Zong H, Tang H, Wang L, Ke Y, Cai H, Li P, Tang J, Chen H, Drelich A, Peng BH, Hsu J, Tat V, Tseng CK, Song J, Yuan Y, Wu M, Liu J, Yue Y, Zhang X, Wang Z, Yang L, Li J, Ni X, Li H, Xiang Y, Bian Y, Zhang B, Yin H, Dimitrov DS, Gilly J, Han L, Jiang H, Xie Y, Zhu J
PNAS (2025) 122 pp. e2406659122-e2406659122 [ Pubmed: 39908098 DOI: doi:10.1073/pnas.2406659122 ]
- Cryo-em structure of neutralizing antibody 8g3 in complex with ba.1 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Heavy chain of 8g3 (23 kDa, Protein from Homo heidelbergensis)
- Light chain of 8g3 (23 kDa, Protein from Homo sapiens)
Human TPC2 in Complex with Antagonist (S)-SG-094
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ouo
Q-score: 0.509
Chi G, Jaslan D, Kudrina V, Bock J, Li H, Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M, Bracher F, Grimm C, Durr KL
Structure (2024) 32 pp. 1137-1149.e4 [ Pubmed: 38815576 DOI: doi:10.1016/j.str.2024.05.005 ]
- (1s)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1h-isoquinoline (451 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Two pore channel protein 2 (85 kDa, Protein from Homo sapiens)
- Homodimeric complex of human two-pore channel 2 (tpc2) (150 kDa, Complex from Homo sapiens)
- 2-{[(4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranoside (1 kDa, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Di-heneicosanoyl phosphatidyl choline (875 Da, Ligand)
Human TPC2 in Complex withAntagonist (R)-SG-094
Chi G, Jaslan D, Kudrina V, Bock J, Li H, Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M, Bracher F, Grimm C, Durr KL
Structure (2024) 32 pp. 1137-1149.e4 [ Pubmed: 38815576 DOI: doi:10.1016/j.str.2024.05.005 ]