Cryo-EM structure of ETBR bound with BQ3020
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Bq3020 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Exo-alpha-sialidase,endothelin receptor type b (94 kDa, Protein from Homo sapiens)
- Complex of protein gsq with etb and bq3020 (Complex from Homo sapiens)
Cryo-EM structure of ETBR bound with Endothelin1
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Complex of protein gs/q with etb and endothelin-1 (Complex from Homo sapiens)
- Exo-alpha-sialidase,endothelin receptor type b (94 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
Cryo-EM structure of ETAR bound with Endothelin1
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor (77 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Complex of protein gs/q with eta and endothelin-1 (Complex from Homo sapiens)
Cryo-EM structure of ETAR bound with Macitentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Macitentan (588 Da, Ligand)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Complex of endothelin receptor type a with macitentan (Complex from Homo sapiens)
Cryo-EM structure of ETAR bound with Ambrisentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Complex of endothelin receptor type a with ambrisentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Ambrisentan (378 Da, Ligand)
Cryo-EM structure of ETAR bound with Zibotentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Zibotentan (424 Da, Ligand)
- Complex of endothelin receptor type a with zibotentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state I
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8yhd
Q-score: 0.5
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- A protein (70 kDa, Protein from metagenome)
- Rna (35-mer) (16 kDa, RNA from metagenome)
- A protein (Complex from metagenome)
- Zinc ion (65 Da, Ligand)
- A protein (27 kDa, Protein from metagenome)
- Rna (53-mer) (21 kDa, RNA from metagenome)
- A protein (22 kDa, Protein from metagenome)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8yhe
Q-score: 0.506
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Rna (29-mer) (16 kDa, RNA from metagenome)
- Protein structure (70 kDa, Protein from metagenome)
- Zinc ion (65 Da, Ligand)
- Protein structure (27 kDa, Protein from metagenome)
- Rna (46-mer) (15 kDa, RNA from metagenome)
- Protein structure (22 kDa, Protein from metagenome)
- Protein structure (Complex from metagenome)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8z4j
Q-score: 0.507
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Protein structure (27 kDa, Protein from metagenome)
- Protein structure (22 kDa, Protein from metagenome)
- A protein (Complex from metagenome)
- Zinc ion (65 Da, Ligand)
- Rna (38-mer) (19 kDa, RNA from metagenome)
- Protein structure (70 kDa, Protein from metagenome)
- Rna (34-mer) (19 kDa, RNA from metagenome)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8z4l
Q-score: 0.531
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- A protein (Complex from metagenome)
- Rna (49-mer) (19 kDa, RNA from metagenome)
- Zinc ion (65 Da, Ligand)
- A protein (27 kDa, Protein from metagenome)
- Rna (40-mer) (19 kDa, RNA from metagenome)
- A protein (70 kDa, Protein from metagenome)
- A protein (22 kDa, Protein from metagenome)