Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn7
Q-score: 0.548
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- 4-(1h-imidazol-4-ylmethyl)pyridine (159 Da, Ligand)
- Immethridine-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn8
Q-score: 0.544
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Proxyfan-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 5-(3-phenylmethoxypropyl)-1h-imidazole (216 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8yn2
Q-score: 0.578
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Histamine-h1r-minigq-scfv16 complex (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Histamine h1 receptor (80 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8yn3
Q-score: 0.623
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Engineered guanine nucleotide,binding protein g(s) subunit alpha (29 kDa, Protein from synthetic construct)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Nanobody nb35 (15 kDa, Protein from synthetic construct)
- Histamine (111 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine-h2r-minigs-nb35 complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8yn4
Q-score: 0.515
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Histamine-h2r-minigq-scfv16 complex (Complex from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yn5
Q-score: 0.589
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Histamine (111 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Histamine-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn6
Q-score: 0.546
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 2-(1~{h}-imidazol-5-yl)ethyl carbamimidothioate (170 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Imetit-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H4 receptor in complex with histamine and Gi
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8yn9
Q-score: 0.628
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Histamine-h4r-gi-scfv16 complex (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (71 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of histamine H4 receptor in complex with immepip and Gi
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8yna
Q-score: 0.586
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ DOI: doi:10.1038/s41467-024-52585-y Pubmed: 39333117 ]
- Immepip-h4r-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the red-shifted Fittonia albivenis PSI-LHCI
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8wgh
Q-score: 0.665
Li X, Huang G, Zhu L, Hao C, Sui SF, Qin X
Nat Commun (2024) 15 pp. 6325-6325 [ DOI: doi:10.1038/s41467-024-50655-9 Pubmed: 39060282 ]
- Phylloquinone (450 Da, Ligand)
- Photosystem i p700 chlorophyll a apoprotein a1 (83 kDa, Protein from Fittonia albivenis)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- Chlorophyll a-b binding protein 2 (28 kDa, Protein from Fittonia albivenis)
- Photosystem i iron-sulfur center (9 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit ii (21 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit xi (23 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit n (18 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit psak (13 kDa, Protein from Fittonia albivenis)
- Beta-carotene (536 Da, Ligand)
- Photosystem i reaction center subunit ix (5 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit vi (15 kDa, Protein from Fittonia albivenis)
- Chlorophyll b (907 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Chlorophyll a-b binding protein 4 (27 kDa, Protein from Fittonia albivenis)
- Photosystem i complex (Complex from Fittonia albivenis)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Photosystem i reaction center subunit viii (15 kDa, Protein from Fittonia albivenis)
- Photosystem i p700 chlorophyll a apoprotein a2 (82 kDa, Protein from Fittonia albivenis)
- (3s,5r,6s,3's,5'r,6's)-5,6,5',6'-diepoxy-5,6,5',6'- tetrahydro-beta,beta-carotene-3,3'-diol (600 Da, Ligand)
- Photosystem i reaction center subunit iv (16 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit iii, chloroplastic (24 kDa, Protein from Fittonia albivenis)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- (3r,3'r,6s)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol (568 Da, Ligand)
- Chlorophyll a-b binding protein 3 (29 kDa, Protein from Fittonia albivenis)
- Heptyl 1-thio-beta-d-glucopyranoside (294 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Chlorophyll a (893 Da, Ligand)
- Chlorophyll a-b binding protein 1 (26 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit o (15 kDa, Protein from Fittonia albivenis)
- Photosystem i reaction center subunit viii (3 kDa, Protein from Fittonia albivenis)