Cryo-EM structure of the Cas9d-sgRNA complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8zq9
Q-score: 0.47
To Be Published
- A protein (86 kDa, Protein from metagenome)
- Rna (128-mer) (51 kDa, RNA from metagenome)
- A protein (Complex from metagenome)
- Zinc ion (65 Da, Ligand)
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
Zhao J, Shen Q, Yong X, Li X, Tian X, Sun S, Xu Z, Zhang X, Zhang L, Yang H, Shao Z, Xu H, Jiang Y, Zhang Y, Yan W
Nat Struct Mol Biol (2025) [ Pubmed: 39824976 DOI: doi:10.1038/s41594-024-01470-9 ]
- [(2r)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate (720 Da, Ligand)
- Water (18 Da, Ligand)
- Lysosomal cholesterol signaling protein (93 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol-bound lychos (Complex from Homo sapiens)
Cryo-EM Structure of MILI(K852A)-piRNA-target (26-nt)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9ij4
Q-score: 0.474
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ Pubmed: 39814893 DOI: doi:10.1038/s41586-024-08438-1 ]
- Magnesium ion (24 Da, Ligand)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Mili(k852a)-pirna-target (26-nt) (Complex from Homo sapiens)
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 9jmz
Q-score: 0.489
Song H, Hao T, Han P, Wang H, Zhang X, Li X, Wang Y, Chen J, Li Y, Jin X, Duan X, Zhang W, Bi Y, Jin R, Sun L, Wang N, Gao GF
Cell (2025) [ DOI: doi:10.1016/j.cell.2025.01.019 Pubmed: 39848246 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human-infecting bovine influenza h5n1 hemagglutinin complexed with avian receptor analog lsta (Complex from Influenza A virus (A/Indonesia/5/2005(H5N1)))
- Hemagglutinin (57 kDa, Protein from Influenza A virus (A/Indonesia/5/2005(H5N1)))
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 9jn0
Q-score: 0.518
Curved structure of mPIEZO1-S2472E
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 8ixn
Q-score: 0.301
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ Pubmed: 39719701 DOI: doi:10.1016/j.neuron.2024.11.020 ]
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- S2472e-curved structure (Complex from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
Flattened structure of mPIEZO1-S2472E
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ixo
Q-score: 0.445
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ Pubmed: 39719701 DOI: doi:10.1016/j.neuron.2024.11.020 ]
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- S2472e-intermediate structure (Complex from Mus musculus)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8z8z
Q-score: 0.589
Xiong Q, Zhu Z, Li T, Li X, Zhou Z, Chao Y, Yang C, Feng S, Qu Q, Li D
Nat Struct Mol Biol (2025) [ Pubmed: 39824977 DOI: doi:10.1038/s41594-024-01474-5 ]
- Water (18 Da, Ligand)
- Lysosomal cholesterol signaling protein,fluorescent protein (127 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Lychos (127 kDa, Complex from Homo sapiens)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (4~{z},7~{z},10~{z},13~{z},16~{z},19~{z})-docosa-4,7,10,13,16,19-hexaenoate (764 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of chanoclavine synthase from Claviceps fusiformis
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 9jdb
Q-score: 0.633
Liu ZW, Wang T, Li X, Shen PP, Huang J-W, Chen C-C, Guo R-T
To Be Published
- Ergot alkaloid synthesis protein c (Complex from Claviceps fusiformis)
- Catalase easc (54 kDa, Protein from Claviceps fusiformis)
- Protoporphyrin ix containing fe (616 Da, Ligand)
Structure of chanoclavine synthase from Claviceps fusiformis in complex with prechanoclavine
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 9jdc
Q-score: 0.693
Liu ZW, Wang T, Li X, Shen PP, Huang J-W, Chen C-C, Guo R-T
To Be Published
- (2~{s})-2-(methylamino)-3-[4-[(1~{e})-3-methylbuta-1,3-dienyl]-1~{h}-indol-3-yl]propanoic acid (284 Da, Ligand)
- Ergot alkaloid synthesis protein c (Complex from Claviceps fusiformis)
- Catalase easc (54 kDa, Protein from Claviceps fusiformis)
- Protoporphyrin ix containing fe (616 Da, Ligand)