Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Resolution: 7.3 Å
EM Method: Single-particle
Fitted PDBs: 7xxl
Q-score: 0.033
Ku Z, Xie X, Lin J, Gao P, Wu B, El Sahili A, Su H, Liu Y, Ye X, Tan EY, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Zou J, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z
Nat Commun (2022) 13 pp. 5552-5552 [ Pubmed: 36138032 DOI: doi:10.1038/s41467-022-33284-y ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor binding domain of wild-type spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rbd bound to fab14 (Complex)
- Fab14 (Complex from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab14 heavy chain (25 kDa, Protein from Homo sapiens)
- Fab14 light chain (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of compact CA16 empty particle in complex with a neutralizing antibody 8C4
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 7yrf
Q-score: 0.433
Zhang C, Liu C, Shi J, Wang Y, Xu C, Ye X, Liu Q, Li X, Qiao W, Yin Y, Cong Y, Huang Z
Nat Commun (2022) 13 pp. 7854-7854 [ DOI: doi:10.1038/s41467-022-35575-w Pubmed: 36543790 ]
- The heavy chain of the antibody 8c4 (22 kDa, Protein from Coxsackievirus A16)
- Cryo-em structure of compact ca16 empty particle in complex with a neutralizing antibody 8c4 (Complex from Coxsackievirus A16)
- Light chain of chain (23 kDa, Protein from Coxsackievirus A16)
- Genome polyprotein (33 kDa, Protein from Coxsackievirus A16)
- Sphingosine (299 Da, Ligand)
- Genome polyprotein (25 kDa, Protein from Coxsackievirus A16)
- Capsid protein vp3 (26 kDa, Protein from Coxsackievirus A16)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7yrh
Q-score: 0.405
Zhang C, Liu C, Shi J, Wang Y, Xu C, Ye X, Liu Q, Li X, Qiao W, Yin Y, Cong Y, Huang Z
Nat Commun (2022) 13 pp. 7854-7854 [ DOI: doi:10.1038/s41467-022-35575-w Pubmed: 36543790 ]
- Genome polyprotein (33 kDa, Protein from Coxsackievirus A16)
- Capsid protein vp1 (33 kDa, Protein from Coxsackievirus A16)
- Sphingosine (299 Da, Ligand)
- Cryo-em structure of compact coxsackievirus a16 empty particle in complex with a neutralizing antibody 9b5 (Complex from Coxsackievirus A16)
- The light chain of the antibody 9b5 (23 kDa, Protein from Coxsackievirus A16)
- The heavy chain of the antibody 9b5 (23 kDa, Protein from Coxsackievirus A16)
- Capsid protein vp3 (26 kDa, Protein from Coxsackievirus A16)
The structure of coxsackievirus A16 mature virion in complex with Fab 8C4
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7y7m
Q-score: 0.513
Zhang C, Liu C, Shi J, Wang Y, Xu C, Ye X, Liu Q, Li X, Qiao W, Yin Y, Cong Y, Huang Z
Nat Commun (2022) 13 pp. 7854-7854 [ DOI: doi:10.1038/s41467-022-35575-w Pubmed: 36543790 ]
- Capsid protein vp2 (27 kDa, Protein from Coxsackievirus A16)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus A16)
- Capsid protein vp1 (33 kDa, Protein from Coxsackievirus A16)
- Sphingosine (299 Da, Ligand)
- Capsid protein vp3 (26 kDa, Protein from Coxsackievirus A16)
- Cryo-em structure of coxsackievirus a16 mature virus in complex with a neutralizing antibody 8c4 (Complex from Coxsackievirus A16)
- The heavy chain of fab 8c4 (22 kDa, Protein from Coxsackievirus A16)
- The light chain of fab 8c4 (23 kDa, Protein from Coxsackievirus A16)
Structure of AtTPC1 with 1 mM Ca2+
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7fhk
Q-score: 0.483
Ye F, Xu L, Li X, Zeng W, Gan N, Zhao C, Yang W, Jiang Y, Guo J
PNAS (2021) 118 [ Pubmed: 34845029 DOI: doi:10.1073/pnas.2113946118 ]
- Attpc1 homodimer (Complex from Arabidopsis thaliana)
- Two pore calcium channel protein 1,gfp (114 kDa, Protein from Human respiratory syncytial virus)
- Calcium ion (40 Da, Ligand)
- Attpc1-cter (1 kDa, Protein from Arabidopsis thaliana)
Structure of AtTPC1 with 50 mM Ca2+
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7fhl
Q-score: 0.45
Ye F, Xu L, Li X, Zeng W, Gan N, Zhao C, Yang W, Jiang Y, Guo J
PNAS (2021) 118 [ Pubmed: 34845029 DOI: doi:10.1073/pnas.2113946118 ]
- Attpc1 homodimer (Complex from Arabidopsis thaliana)
- Two pore calcium channel protein 1,gfp (114 kDa, Protein from Human respiratory syncytial virus)
- Calcium ion (40 Da, Ligand)
- Attpc1-cter (1 kDa, Protein from Arabidopsis thaliana)
Structure of AtTPC1 D240A/D454A/E528A mutant with 50 mM Ca2+