Structure of human Wnt7a bound to WLS and CALR
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tzo
Q-score: 0.494
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X
Cell (2023) 186 pp. 5028-5040.e14 [ DOI: doi:10.1016/j.cell.2023.09.021 Pubmed: 37852257 ]
- Palmitoleic acid (254 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Protein wntless homolog (62 kDa, Protein from Homo sapiens)
- Wnt7a-wls-calr complex (Complex from Homo sapiens)
- Protein wnt-7a (39 kDa, Protein from Homo sapiens)
- Calreticulin (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human Wnt7a bound to WLS and RECK
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8tzp
Q-score: 0.481
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X
Cell (2023) 186 pp. 5028-5040.e14 [ DOI: doi:10.1016/j.cell.2023.09.021 Pubmed: 37852257 ]
- Palmitoleic acid (254 Da, Ligand)
- Protein wntless homolog (62 kDa, Protein from Homo sapiens)
- Protein wnt-7a (39 kDa, Protein from Homo sapiens)
- Reversion-inducing cysteine-rich protein with kazal motifs (106 kDa, Protein from Homo sapiens)
- Wnt7a-wls-reck complex (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human Wnt3a bound to WLS and CALR
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tzr
Q-score: 0.381
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X
Cell (2023) 186 pp. 5028-5040.e14 [ DOI: doi:10.1016/j.cell.2023.09.021 Pubmed: 37852257 ]
- Palmitoleic acid (254 Da, Ligand)
- Protein wnt-3a (39 kDa, Protein from Homo sapiens)
- Protein wntless homolog (62 kDa, Protein from Homo sapiens)
- Calreticulin (48 kDa, Protein from Homo sapiens)
- Wnt3a-wls-calr complex (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Human S1P transporter Spns2 in an inward-facing open conformation (state 1)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8ex4
Q-score: 0.558
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an inward-facing open conformation (state 1*)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8ex6
Q-score: 0.485
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8djk
Q-score: 0.45
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X
Nat Commun (2022) 13 pp. 4273-4273 [ DOI: doi:10.1038/s41467-022-32025-5 Pubmed: 35879350 ]
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase (41 kDa, Protein from Cricetulus griseus)
- Soluble cytochrome b562 (13 kDa, Protein from Escherichia coli)
- Digitonin (1 kDa, Ligand)
- Fab 15b2 light chain (23 kDa, Protein from Mus musculus)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex from Cricetulus griseus)
- Ubia prenyltransferase domain-containing protein 1 (32 kDa, Protein from Cricetulus griseus)
- Fab 15b2 heavy chain (25 kDa, Protein from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8djm
Q-score: 0.468
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X
Nat Commun (2022) 13 pp. 4273-4273 [ DOI: doi:10.1038/s41467-022-32025-5 Pubmed: 35879350 ]
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase (41 kDa, Protein from Cricetulus griseus)
- Soluble cytochrome b562 (13 kDa, Protein from Escherichia coli)
- Digitonin (1 kDa, Ligand)
- Fab 15b2 light chain (23 kDa, Protein from Mus musculus)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex from Cricetulus griseus)
- Ubia prenyltransferase domain-containing protein 1 (32 kDa, Protein from Cricetulus griseus)
- Fab 15b2 heavy chain (25 kDa, Protein from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex)
Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7tuz
Q-score: 0.498
Structure (2022) 30 pp. 1016- [ Pubmed: 35537452 DOI: doi:10.1016/j.str.2022.04.006 ]
- Complex of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 with gi protein (140 kDa, Complex)
- (2s,4as,4bs,7r,8s,8as,9r,10ar)-7-[(2r,3r)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol (418 Da, Ligand)
- G-protein coupled receptor 183 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 183 (43 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
Structure of S1PR2-heterotrimeric G13 signaling complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7t6b
Q-score: 0.506
Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X
Sci Adv (2022) 8 pp. eabn0067-eabn0067 [ Pubmed: 35353559 DOI: doi:10.1126/sciadv.abn0067 ]
- Structure of s1pr2-heterotrimeric g13 signaling complex (Complex from Homo sapiens)
- Sphingosine 1-phosphate receptor 2 (39 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
Structure of Human Dispatched-1 (DISP1)
Resolution: 4.53 Å
EM Method: Single-particle
Fitted PDBs: 6xe6
Q-score: 0.33
Life Sci Alliance (2020) 3 [ Pubmed: 32646883 DOI: doi:10.26508/lsa.202000776 ]
- Protein dispatched homolog 1 (124 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human dispatched-1 in complex with dual-lipidated shh-n (Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)