Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 9jmz
Q-score: 0.489
Song H, Hao T, Han P, Wang H, Zhang X, Li X, Wang Y, Chen J, Li Y, Jin X, Duan X, Zhang W, Bi Y, Jin R, Sun L, Wang N, Gao GF
Cell (2025) [ Pubmed: 39848246 DOI: doi:10.1016/j.cell.2025.01.019 ]
- Human-infecting bovine influenza h5n1 hemagglutinin complexed with avian receptor analog lsta (Complex from Influenza A virus (A/Indonesia/5/2005(H5N1)))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hemagglutinin (57 kDa, Protein from Influenza A virus (A/Indonesia/5/2005(H5N1)))
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 9jn0
Q-score: 0.518
Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Structure of wild type human PSS1
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024) 187 pp. 5665-5678.e18 [ Pubmed: 39208797 DOI: doi:10.1016/j.cell.2024.08.004 ]
- Calcium ion (40 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pss1 (Complex from Homo sapiens)
- (2r)-3-{[(s)-hydroxy{[(1r,2r,3r,4r,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate (811 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Water (18 Da, Ligand)
- Phosphatidylserine synthase 1 (48 kDa, Protein from Homo sapiens)
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024) 187 pp. 5665-5678.e18 [ Pubmed: 39208797 DOI: doi:10.1016/j.cell.2024.08.004 ]
- Calcium ion (40 Da, Ligand)
- Phosphatidylserine synthase 1 (56 kDa, Protein from Homo sapiens)
- Human pss1-p269s (Complex from Homo sapiens)
Structure of inhibitor-bound human PSS1
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024) 187 pp. 5665-5678.e18 [ Pubmed: 39208797 DOI: doi:10.1016/j.cell.2024.08.004 ]
- Calcium ion (40 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- (7p)-7-[(4s)-4-{4-[3,5-bis(trifluoromethyl)phenoxy]phenyl}-5-(2,2-difluoropropyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-1,3-benzoxazol-2(3h)-one (638 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1r,2r,3r,4r,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate (811 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Water (18 Da, Ligand)
- Phosphatidylserine synthase 1 (48 kDa, Protein from Homo sapiens)
- Inhibitor-bound human pss1 (Complex from Homo sapiens)
A neutralizing nanobody VHH60 against wt SARS-CoV-2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xki
Q-score: 0.441
Liu Q, Lu Y, Cai C, Huang Y, Zhou L, Guan Y, Fu S, Lin Y, Yan H, Zhang Z, Li X, Yang X, Yang H, Guo H, Lan K, Chen Y, Hou SC, Xiong Y
Cell Death Dis (2024) 15 pp. 458-458 [ Pubmed: 38937437 DOI: doi:10.1038/s41419-024-06802-7 ]
- Sars-cov-2 spike glycoprotein complex with vhh60 nanobody (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nanobody vhh60 (13 kDa, Protein from synthetic construct)
- Nanobody (Complex from synthetic construct)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
human connexin-36 gap junction channel in complex with mefloquine
Resolution: 2.13 Å
EM Method: Single-particle
Fitted PDBs: 8qoj
Q-score: 0.657
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, Li X, Blum TB, Picotti P, Gervasio FL, Korkhov VM
Cell Discov (2024) 10 pp. 68-68 [ Pubmed: 38890333 DOI: doi:10.1038/s41421-024-00691-y ]
- (11r,12s)- mefloquine (378 Da, Ligand)
- Water (18 Da, Ligand)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
- Human connexin-36 gap junction channel in complex with mefloquine (Complex from Homo sapiens)
human connexin-36 gap junction channel
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8r7p
Q-score: 0.62
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, Li X, Blum TB, Picotti P, Gervasio FL, Korkhov VM
Cell Discov (2024) 10 pp. 68-68 [ Pubmed: 38890333 DOI: doi:10.1038/s41421-024-00691-y ]
- Human connexin-36 gap junction channel (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
human connexin-36 gap junction channel in complex with quinine
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8r7q
Q-score: 0.602
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, Li X, Blum TB, Picotti P, Gervasio FL, Korkhov VM
Cell Discov (2024) 10 pp. 68-68 [ Pubmed: 38890333 DOI: doi:10.1038/s41421-024-00691-y ]
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
- Human connexin-36 gap junction channel in complex with quinine (Complex from Homo sapiens)
- Quinine (324 Da, Ligand)