Structure of wild type human PSS1
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024) 187 pp. 5665-5678.e18 [ Pubmed: 39208797 DOI: doi:10.1016/j.cell.2024.08.004 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Water (18 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1r,2r,3r,4r,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate (811 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Phosphatidylserine synthase 1 (48 kDa, Protein from Homo sapiens)
- Pss1 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024) 187 pp. 5665-5678.e18 [ Pubmed: 39208797 DOI: doi:10.1016/j.cell.2024.08.004 ]
- Human pss1-p269s (Complex from Homo sapiens)
- Phosphatidylserine synthase 1 (56 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Structure of inhibitor-bound human PSS1
Long T, Li D, Vale G, Jiang Y, Schmiege P, Yang ZJ, McDonald JG, Li X
Cell (2024) 187 pp. 5665-5678.e18 [ Pubmed: 39208797 DOI: doi:10.1016/j.cell.2024.08.004 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Water (18 Da, Ligand)
- Inhibitor-bound human pss1 (Complex from Homo sapiens)
- (7p)-7-[(4s)-4-{4-[3,5-bis(trifluoromethyl)phenoxy]phenyl}-5-(2,2-difluoropropyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-1,3-benzoxazol-2(3h)-one (638 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1r,2r,3r,4r,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate (811 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Phosphatidylserine synthase 1 (48 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Human VMAT2 in complex with tetrabenazine
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8t69
Q-score: 0.558
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ DOI: doi:10.1038/s41586-023-06727-9 Pubmed: 37914936 ]
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
- Human vmat2 in complex with tetrabenazine (Complex from Homo sapiens)
- Tetrabenazine (317 Da, Ligand)
Human VMAT2 in complex with reserpine
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8t6a
Q-score: 0.504
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ DOI: doi:10.1038/s41586-023-06727-9 Pubmed: 37914936 ]
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
- Human vmat2 in complex with reserpine (Complex from Homo sapiens)
- Reserpine (608 Da, Ligand)
Human VMAT2 in complex with serotonin
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8t6b
Q-score: 0.39
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ DOI: doi:10.1038/s41586-023-06727-9 Pubmed: 37914936 ]
- Human vmat2 in complex with serotonin (Complex from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
Structure of human Wnt7a bound to WLS and CALR
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tzo
Q-score: 0.494
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X
Cell (2023) 186 pp. 5028-5040.e14 [ DOI: doi:10.1016/j.cell.2023.09.021 Pubmed: 37852257 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Palmitoleic acid (254 Da, Ligand)
- Calreticulin (48 kDa, Protein from Homo sapiens)
- Wnt7a-wls-calr complex (Complex from Homo sapiens)
- Protein wnt-7a (39 kDa, Protein from Homo sapiens)
- Protein wntless homolog (62 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Structure of human Wnt7a bound to WLS and RECK
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8tzp
Q-score: 0.481
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X
Cell (2023) 186 pp. 5028-5040.e14 [ DOI: doi:10.1016/j.cell.2023.09.021 Pubmed: 37852257 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Palmitoleic acid (254 Da, Ligand)
- Reversion-inducing cysteine-rich protein with kazal motifs (106 kDa, Protein from Homo sapiens)
- Protein wnt-7a (39 kDa, Protein from Homo sapiens)
- Protein wntless homolog (62 kDa, Protein from Homo sapiens)
- Wnt7a-wls-reck complex (Complex from Homo sapiens)
Structure of human Wnt3a bound to WLS and CALR
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tzr
Q-score: 0.381
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X
Cell (2023) 186 pp. 5028-5040.e14 [ DOI: doi:10.1016/j.cell.2023.09.021 Pubmed: 37852257 ]
- Wnt3a-wls-calr complex (Complex from Homo sapiens)
- Protein wnt-3a (39 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Palmitoleic acid (254 Da, Ligand)
- Calreticulin (48 kDa, Protein from Homo sapiens)
- Protein wntless homolog (62 kDa, Protein from Homo sapiens)
Structure of mouse Myomaker bound to Fab18G7 in detergent
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8t03
Q-score: 0.574
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Fab18g7 (Complex from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Complex of mouse myomaker and fab18g7 (Complex)
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Mouse myomaker (Complex from Mus musculus)
- Protein myomaker (24 kDa, Protein from Mus musculus)