Cryo-EM Structure of MILI(K852A)-piRNA-target (26-nt)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9ij4
Q-score: 0.474
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Mili(k852a)-pirna-target (26-nt) (Complex from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, bilobed)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9iiy
Q-score: 0.315
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (5'-r(p*cp*gp*up*cp*up*ap*up*ap*cp*ap*ap*cp*cp*gp*ap*up*cp*ap*gp*cp*u)-3') (6 kDa, RNA from Homo sapiens)
- Efpiwi-pirna-target (25-nt, bilobed) (Complex from Homo sapiens)
- Piwi (110 kDa, Protein from Ephydatia fluviatilis)
- Rna (5'-r(p*up*ap*gp*cp*ap*gp*ap*up*cp*gp*gp*up*up*gp*up*ap*up*ap*gp*ap*cp*g)-3') (7 kDa, RNA from Homo sapiens)
Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, comma)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9iiz
Q-score: 0.214
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (5'-r(p*ap*gp*cp*cp*ap*ap*gp*up*up*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*a)-3') (7 kDa, RNA from Homo sapiens)
- Rna (25-mer) (7 kDa, RNA from Homo sapiens)
- Piwi (110 kDa, Protein from Ephydatia fluviatilis)
- Efpiwi-pirna-target (25-nt, comma) (Complex from Homo sapiens)
Cryo-EM Structure of MILI-piRNA-target (8-nt)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ij0
Q-score: 0.417
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (5'-r(p*gp*ap*up*gp*gp*up*ap*a)-3') (2 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Mili-pirna-target (8-nt) (Complex from Homo sapiens)
Cryo-EM Structure of MILI-piRNA-target (22-nt, bilobed)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ij1
Q-score: 0.325
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Mili-pirna-target (22-nt, bilobed) (Complex from Homo sapiens)
- Rna (5'-r(p*cp*ap*ap*gp*up*up*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*a)-3') (6 kDa, RNA from Homo sapiens)
Cryo-EM Structure of MILI-piRNA-target (22-nt, comma)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9ij2
Q-score: 0.188
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Mili-pirna-target (22-nt, comma) (Complex from Homo sapiens)
- Rna (5'-r(p*cp*ap*ap*gp*up*up*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*a)-3') (6 kDa, RNA from Homo sapiens)
- Rna (5'-r(p*up*up*ap*cp*cp*ap*up*cp*ap*ap*cp*ap*up*gp*gp*ap*ap*ap*cp*up*up*g)-3') (6 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
Cryo-EM Structure of MILI-piRNA-target (26-nt)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9ij3
Q-score: 0.463
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Mili-pirna-target (26-nt) (Complex from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Manganese (ii) ion (54 Da, Ligand)
Cryo-EM Structure of MILI(K853A)-piRNA-target
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9ij5
Q-score: 0.461
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Mili(k853a)-pirna-target (Complex from Homo sapiens)
Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7yfq
Q-score: 0.435
Li Z, Li Z, Zhang Y, Zhou L, Xu Q, Li L, Zeng L, Xue J, Niu H, Zhong J, Yu Q, Li D, Gui M, Huang Y, Tu S, Zhang Z, Song CQ, Wu J, Shen EZ
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01287-6 Pubmed: 38658622 ]
- Efpiwi(n959k)-pirna-16nt target (Complex)
- Magnesium ion (24 Da, Ligand)
- Efpiwi(n959k) (Complex from Ephydatia fluviatilis)
- Rna (5'-r(*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*ap*a)-3') (5 kDa, RNA from Homo sapiens)
- Pirna (7 kDa, RNA from Homo sapiens)
- Rna (Complex)
- Piwi (92 kDa, Protein from Ephydatia fluviatilis)
Cryo-EM structure of Hili in complex with piRNA
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yfx
Q-score: 0.425
Li Z, Li Z, Zhang Y, Zhou L, Xu Q, Li L, Zeng L, Xue J, Niu H, Zhong J, Yu Q, Li D, Gui M, Huang Y, Tu S, Zhang Z, Song CQ, Wu J, Shen EZ
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01287-6 Pubmed: 38658622 ]
- Magnesium ion (24 Da, Ligand)
- Pirna (8 kDa, RNA from Homo sapiens)
- Hili (Complex from Homo sapiens)
- Hili-pirna (Complex)
- Piwi-like protein 2 (114 kDa, Protein from Homo sapiens)
- Pirna (Complex)