Cryo-EM Structure of MILI(K852A)-piRNA-target (26-nt)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9ij4
Q-score: 0.474
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Mili(k852a)-pirna-target (26-nt) (Complex from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, bilobed)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9iiy
Q-score: 0.315
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (5'-r(p*cp*gp*up*cp*up*ap*up*ap*cp*ap*ap*cp*cp*gp*ap*up*cp*ap*gp*cp*u)-3') (6 kDa, RNA from Homo sapiens)
- Efpiwi-pirna-target (25-nt, bilobed) (Complex from Homo sapiens)
- Piwi (110 kDa, Protein from Ephydatia fluviatilis)
- Rna (5'-r(p*up*ap*gp*cp*ap*gp*ap*up*cp*gp*gp*up*up*gp*up*ap*up*ap*gp*ap*cp*g)-3') (7 kDa, RNA from Homo sapiens)
Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, comma)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9iiz
Q-score: 0.214
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (5'-r(p*ap*gp*cp*cp*ap*ap*gp*up*up*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*a)-3') (7 kDa, RNA from Homo sapiens)
- Rna (25-mer) (7 kDa, RNA from Homo sapiens)
- Piwi (110 kDa, Protein from Ephydatia fluviatilis)
- Efpiwi-pirna-target (25-nt, comma) (Complex from Homo sapiens)
Cryo-EM Structure of MILI-piRNA-target (8-nt)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ij0
Q-score: 0.417
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (5'-r(p*gp*ap*up*gp*gp*up*ap*a)-3') (2 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Mili-pirna-target (8-nt) (Complex from Homo sapiens)
Cryo-EM Structure of MILI-piRNA-target (22-nt, bilobed)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ij1
Q-score: 0.325
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Mili-pirna-target (22-nt, bilobed) (Complex from Homo sapiens)
- Rna (5'-r(p*cp*ap*ap*gp*up*up*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*a)-3') (6 kDa, RNA from Homo sapiens)
Cryo-EM Structure of MILI-piRNA-target (22-nt, comma)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9ij2
Q-score: 0.188
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Mili-pirna-target (22-nt, comma) (Complex from Homo sapiens)
- Rna (5'-r(p*cp*ap*ap*gp*up*up*up*cp*cp*ap*up*gp*up*up*gp*ap*up*gp*gp*up*a)-3') (6 kDa, RNA from Homo sapiens)
- Rna (5'-r(p*up*up*ap*cp*cp*ap*up*cp*ap*ap*cp*ap*up*gp*gp*ap*ap*ap*cp*up*up*g)-3') (6 kDa, RNA from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
Cryo-EM Structure of MILI-piRNA-target (26-nt)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9ij3
Q-score: 0.463
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Mili-pirna-target (26-nt) (Complex from Homo sapiens)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Manganese (ii) ion (54 Da, Ligand)
Cryo-EM Structure of MILI(K853A)-piRNA-target
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9ij5
Q-score: 0.461
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, Lu X, Li X, Wan L, Xue J, Huang J, Zhen Y, Zhang Z, Wu J, Shen EZ
Nature (2025) [ DOI: doi:10.1038/s41586-024-08438-1 Pubmed: 39814893 ]
- Rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Rna (25-mer) (8 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Piwi-like protein 2 (109 kDa, Protein from Mus musculus)
- Mili(k853a)-pirna-target (Complex from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6a90
Q-score: 0.56
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and dc1a (200 kDa, Complex)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
- Sodium ion (22 Da, Ligand)
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6a91
Q-score: 0.515
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Water (18 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)