Cryo-EM structure of PfAgo-guide DNA-target DNA complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jpx
Q-score: 0.575
Wang L, Chen W, Zhang C, Xie X, Huang F, Chen M, Mao W, Yu N, Wei Q, Ma L, Li Z
Mol Cell (2024) 84 pp. 675-686.e4 [ Pubmed: 38295801 DOI: doi:10.1016/j.molcel.2024.01.004 ]
- Magnesium ion (24 Da, Ligand)
- Target dna (5 kDa, DNA from Pyrococcus furiosus DSM 3638)
- Excess dna (1 kDa, DNA from Pyrococcus furiosus DSM 3638)
- Cryo-em structure of a pfago-guide dna-target dna complex (Complex from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1))
- Protein argonaute (90 kDa, Protein from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1))
- Guide dna (5 kDa, DNA from Pyrococcus furiosus DSM 3638)
Cryo-EM structure of TtdAgo-guide DNA-target DNA complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wd8
Q-score: 0.593
Wang L, Chen W, Zhang C, Xie X, Huang F, Chen M, Mao W, Yu N, Wei Q, Ma L, Li Z
Mol Cell (2024) 84 pp. 675-686.e4 [ Pubmed: 38295801 DOI: doi:10.1016/j.molcel.2024.01.004 ]
- Dna binding protein (Complex)
- Magnesium ion (24 Da, Ligand)
- Argonaute family protein (87 kDa, Protein from Thermococcus thioreducens)
- Zinc ion (65 Da, Ligand)
- Target dna (5 kDa, DNA from Thermus thermophilus)
- Cryo-em structure of ttdago-guide dna-target dna complex (Complex from Thermus thermophilus)
- Dna (Complex)
- Guide dna (5 kDa, DNA from Thermus thermophilus)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7vdh
Q-score: 0.53
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{n}-methyl-ethanamine (519 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with c48/80, state2 (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7vdl
Q-score: 0.5
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The pseudoallergen receptor mrgprx2 complex with circular cortistatin-14 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Circular cortistatin-14 (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vdm
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- The pseudoallergen receptor mrgprx2 complex with substance p (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Peptide from protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12. state1
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7vuy
Q-score: 0.509
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state1 (Complex from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7vuz
Q-score: 0.459
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state2 (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7vv0
Q-score: 0.469
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Cholesterol (386 Da, Ligand)
- Peptide from pro-adrenomedullin (1 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, local (Complex from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7vv3
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with linear cortistatin-14 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7vv4
Q-score: 0.471
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Cholesterol (386 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with linear cortistatin-14, local (Complex from Homo sapiens)
- Circular cortistatin-14 (1 kDa, Protein from Homo sapiens)