Cryo-EM structure of urea bound human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xda
Q-score: 0.54
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
- Homotrimer complex of human urea transporter (Complex from Homo sapiens)
- Urea (60 Da, Ligand)
- Water (18 Da, Ligand)
- Urea transporter 2 (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xdd
Q-score: 0.524
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
- Homotrimer complex of human urea transporter (Complex from Homo sapiens)
- 8-hydroxyquinoline-2-carboxylic acid (189 Da, Ligand)
- Urea transporter 2 (43 kDa, Protein from Homo sapien)
- 1-(3-methoxyphenyl)methanamine (137 Da, Ligand)
Cryo-EM structure of TIR-APAZ/Ago-gRNA-DNA complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8i87
Q-score: 0.53
Wang X, Li X, Yu G, Zhang L, Zhang C, Wang Y, Liao F, Wen Y, Yin H, Liu X, Wei Y, Li Z, Deng Z, Zhang H
Cell Res (2023) 33 pp. 699-711 [ DOI: doi:10.1038/s41422-023-00839-7 Pubmed: 37311833 ]
- Tir-apaz/ago-grna-dna complex (Complex from Maribacter polysiphoniae)
- Rna (5'-r(p*up*gp*ap*gp*gp*up*ap*gp*up*ap*gp*gp*up*up*gp*up*ap*up*a)-3') (6 kDa, RNA from Maribacter polysiphoniae)
- Dna (5'-d(p*tp*ap*tp*ap*cp*ap*ap*cp*cp*tp*ap*cp*tp*ap*cp*cp*tp*cp*a)-3') (5 kDa, DNA from Maribacter polysiphoniae)
- Magnesium ion (24 Da, Ligand)
- Piwi domain-containing protein (58 kDa, Protein from Maribacter polysiphoniae)
- Tir domain-containing protein (53 kDa, Protein from Maribacter polysiphoniae)
Cryo-EM structure of the target ssDNA-bound SIR2-APAZ/Ago-gRNA quaternary complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8in8
Q-score: 0.504
Wang X, Li X, Yu G, Zhang L, Zhang C, Wang Y, Liao F, Wen Y, Yin H, Liu X, Wei Y, Li Z, Deng Z, Zhang H
Cell Res (2023) 33 pp. 699-711 [ DOI: doi:10.1038/s41422-023-00839-7 Pubmed: 37311833 ]
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*ap*ap*cp*gp*ap*cp*gp*tp*cp*tp*ap*ap*gp*ap*ap*ap*cp*cp*ap*tp*tp*ap*a)-3') (7 kDa, DNA from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA))
- Rna (5'-r(p*ap*up*ap*ap*up*gp*gp*up*up*up*cp*up*up*ap*gp*ap*cp*gp*up*cp*gp*up*up*u)-3') (7 kDa, RNA from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA))
- Sir2 superfamily protein (66 kDa, Protein from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA))
- Cryo-em structure of the target ssdna-bound sir2-apaz/ago-grna quaternary complex (Complex from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA))
- Piwi domain protein (53 kDa, Protein from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA))
cryo-EM structure of a bacterial dioxygenase
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8h2t
Q-score: 0.596
Ma Y, Li X, Wang F, Zhang L, Zhou S, Che X, Yu D, Liu X, Li Z, Sun H, Yu G, Zhang H
PLoS Biol (2023) 21 pp. e3002189-e3002189 [ Pubmed: 37459330 DOI: doi:10.1371/journal.pbio.3002189 ]
- Rieske (2fe-2s) domain protein (49 kDa, Protein from Variovorax paradoxus)
- Enzyme complex (Complex from Variovorax paradoxus)
- Aromatic-ring-hydroxylating dioxygenase beta subunit (18 kDa, Protein from Variovorax paradoxus)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7wp8
Q-score: 0.441
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk1628x in complex with three neutralizing antibodies (Complex from Mus musculus)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2b4 light chain (12 kDa, Protein from Mus musculus)
- Spike protein stfk1628x (Complex)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (20 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2b4 heavy chain (13 kDa, Protein from Mus musculus)
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7wp6
Q-score: 0.438
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- 36h6 light chain (12 kDa, Protein from Mus musculus)
- Spike protein stfk (Complex)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 36h6 heavy chain (13 kDa, Protein from Mus musculus)
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk in complex with three neutralizing antibodies (Complex from Mus musculus)
Cryo-EM structure of the PGE2-bound EP2-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7cx2
Q-score: 0.536
Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y
Sci Adv (2021) 7 [ Pubmed: 33811074 DOI: doi:10.1126/sciadv.abf1268 ]
- Water (18 Da, Ligand)
- Nb35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Ep2 (Complex from Homo sapiens)
- Prostaglandin e2 receptor ep2 subtype (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pge2-bound ep2-gs complex (Complex)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Gs (Complex from Homo sapiens)
Cryo-EM structure of the Evatanepag-bound EP2-Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7cx4
Q-score: 0.543
Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y
Sci Adv (2021) 7 [ Pubmed: 33811074 DOI: doi:10.1126/sciadv.abf1268 ]
- Nb35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Ep2 (Complex from Homo sapiens)
- Prostaglandin e2 receptor ep2 subtype (39 kDa, Protein from Homo sapiens)
- 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid (468 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pge2-bound ep2-gs complex (Complex)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Gs (Complex from Homo sapiens)
CryoEM structure of the LbCas12a-crRNA-AcrVA4 complex
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 6nma
Q-score: 0.489
Zhang H, Li Z, Daczkowski CM, Gabel C, Mesecar AD, Chang L
Cell Host Microbe (2019) 25 pp. 815- [ Pubmed: 31155345 DOI: doi:10.1016/j.chom.2019.05.004 ]
- Acrva1 (27 kDa, Protein from Moraxella bovoculi)
- Magnesium ion (24 Da, Ligand)
- Rna (12 kDa, RNA from Lachnospiraceae bacterium ND2006)
- Protein complex 4 (Complex from Lachnospiraceae bacterium ND2006)
- Cpf1 (143 kDa, Protein from Lachnospiraceae bacterium ND2006)