SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of r1-26 fab (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Sars-cov-2 spike trimer (6p) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r1-26 fab (25 kDa, Protein from Homo sapiens)
- R1-26 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) in complex with three r1-26 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, focused refinement of RBD-Fab region
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Light chain of r1-26 fab (13 kDa, Protein from Homo sapiens)
- Heavy chain of r1-26 fab (15 kDa, Protein from Homo sapiens)
- R1-26 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) in complex with three r1-26 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike trimer (6P) in complex with two H18 and two R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- H18 fab (Complex from Homo sapiens)
- R1-32 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) in complex with two h18 and two r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (6p) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- H18 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (6p) in complex with three h18 and three r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- R1-32 fab (Complex from Homo sapiens)
- Spike glycoprotein,fibritin,expression tag (141 kDa, Protein from synthetic construct)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (6p) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 S1 in complex with H18 and R1-32 Fab
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- H18 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s1 in complex with h18 and r1-32 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- R1-32 fab (Complex from Homo sapiens)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ Pubmed: 39217172 DOI: doi:10.1038/s41467-024-51770-3 ]
- H18 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- R1-32 fab (Complex from Homo sapiens)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Dimer of sars-cov-2 s1 in complex with h18 and r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7wp8
Q-score: 0.441
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk1628x in complex with three neutralizing antibodies (Complex from Mus musculus)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2b4 light chain (12 kDa, Protein from Mus musculus)
- Spike protein stfk1628x (Complex)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (20 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2b4 heavy chain (13 kDa, Protein from Mus musculus)
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7wp6
Q-score: 0.438
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- 36h6 light chain (12 kDa, Protein from Mus musculus)
- Spike protein stfk (Complex)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 36h6 heavy chain (13 kDa, Protein from Mus musculus)
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk in complex with three neutralizing antibodies (Complex from Mus musculus)