Cryo-EM structure of opioid receptor with biased agonist
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8y45
Q-score: 0.407
Cheng L, Miao Z, Liu S, Li Z, Fu H, Xu C, Hu S, Zhao C, Liu Y, Zhao T, Liu W, Wang H, Liu R, Yan W, Tang X, Liu J, Shao Z, Ke B
Nat Commun (2024) 15 pp. 8284-8284 [ DOI: doi:10.1038/s41467-024-52601-1 Pubmed: 39333070 ]
- Delta-type opioid receptor (36 kDa, Protein from Homo sapiens)
- Cryo-em structure of opioid receptor with biased agonist (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- ~{n},~{n}-diethyl-4-(5-oxidanylspiro[chromene-2,4'-piperidine]-4-yl)benzamide (392 Da, Ligand)
SARS-CoV-2 BA.2 variant spike protein in complex with Fab BD55-5840
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7x6a
Q-score: 0.356
Cao Y, Yisimayi A, Jian F, Song W, Xiao T, Wang L, Du S, Wang J, Li Q, Chen X, Yu Y, Wang P, Zhang Z, Liu P, An R, Hao X, Wang Y, Wang J, Feng R, Sun H, Zhao L, Zhang W, Zhao D, Zheng J, Yu L, Li C, Zhang N, Wang R, Niu X, Yang S, Song X, Chai Y, Hu Y, Shi Y, Zheng L, Li Z, Gu Q, Shao F, Huang W, Jin R, Shen Z, Wang Y, Wang X, Xiao J, Xie XS
Nature (2022) 608 pp. 593-602 [ Pubmed: 35714668 DOI: doi:10.1038/s41586-022-04980-y ]
- Heavy chain of fab bd55-5840 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 ba.2 variant spike protein in complex with fab bd55-5840 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab bd55-5840 (Complex)
- Light chain of fab bd55-5840 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 ba.2 variant spike protein (Complex from Homo sapiens)
Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-3152 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wr8
Q-score: 0.48
Cao Y, Yisimayi A, Jian F, Song W, Xiao T, Wang L, Du S, Wang J, Li Q, Chen X, Yu Y, Wang P, Zhang Z, Liu P, An R, Hao X, Wang Y, Wang J, Feng R, Sun H, Zhao L, Zhang W, Zhao D, Zheng J, Yu L, Li C, Zhang N, Wang R, Niu X, Yang S, Song X, Chai Y, Hu Y, Shi Y, Zheng L, Li Z, Gu Q, Shao F, Huang W, Jin R, Shen Z, Wang Y, Wang X, Xiao J, Xie XS
Nature (2022) 608 pp. 593-602 [ Pubmed: 35714668 DOI: doi:10.1038/s41586-022-04980-y ]
- Bd55-3152h (27 kDa, Protein from Homo sapiens)
- Bd55-3152l (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Complex of bd55-3152 with s6p (Complex from Homo sapiens)
Local structure of BD55-3372 and delta spike
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7wro
Q-score: 0.482
Cao Y, Yisimayi A, Jian F, Song W, Xiao T, Wang L, Du S, Wang J, Li Q, Chen X, Yu Y, Wang P, Zhang Z, Liu P, An R, Hao X, Wang Y, Wang J, Feng R, Sun H, Zhao L, Zhang W, Zhao D, Zheng J, Yu L, Li C, Zhang N, Wang R, Niu X, Yang S, Song X, Chai Y, Hu Y, Shi Y, Zheng L, Li Z, Gu Q, Shao F, Huang W, Jin R, Shen Z, Wang Y, Wang X, Xiao J, Xie XS
Nature (2022) 608 pp. 593-602 [ Pubmed: 35714668 DOI: doi:10.1038/s41586-022-04980-y ]
- 3372l (11 kDa, Protein from Homo sapiens)
- Spike protein s1 (20 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- 3372h (13 kDa, Protein from Homo sapiens)
- Bd55-3372 (Complex from Homo sapiens)
- Delta rbd (Complex from Severe acute respiratory syndrome coronavirus)
- Local structure of bd55-3372 and delta rbd (Complex)
Local resolution of BD55-5840 Fab and SARS-COV2 Omicron RBD
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7wrz
Q-score: 0.544
Cao Y, Yisimayi A, Jian F, Song W, Xiao T, Wang L, Du S, Wang J, Li Q, Chen X, Yu Y, Wang P, Zhang Z, Liu P, An R, Hao X, Wang Y, Wang J, Feng R, Sun H, Zhao L, Zhang W, Zhao D, Zheng J, Yu L, Li C, Zhang N, Wang R, Niu X, Yang S, Song X, Chai Y, Hu Y, Shi Y, Zheng L, Li Z, Gu Q, Shao F, Huang W, Jin R, Shen Z, Wang Y, Wang X, Xiao J, Xie XS
Nature (2022) 608 pp. 593-602 [ Pubmed: 35714668 DOI: doi:10.1038/s41586-022-04980-y ]
- Bd55-5840l (11 kDa, Protein from SARS coronavirus B012)
- Bd55-5840h (13 kDa, Protein from SARS coronavirus B012)
- Spike protein s1 (21 kDa, Protein from SARS coronavirus B012)
- Local resolution of bd55-5840 fab and sars-cov2 omicron rbd (Complex from Homo sapiens)
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 7xcr
Q-score: 0.571
Ai H, Sun M, Liu A, Sun Z, Liu T, Cao L, Liang L, Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H, Zhao S, Li JB, Lou Z, Liu L
Nat Chem Biol (2022) 18 pp. 972-980 [ Pubmed: 35739357 DOI: doi:10.1038/s41589-022-01067-7 ]
- Histone h4 (10 kDa, Protein from Homo sapiens)
- Complex of dot1l(1-416) and h2bk34ub nucleosome (Complex from Homo sapiens)
- Histone-lysine n-methyltransferase, h3 lysine-79 specific (37 kDa, Protein from Homo sapiens)
- Dna (146-mer) (44 kDa, DNA from synthetic construct)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Histone domain-containing protein (11 kDa, Protein from synthetic construct)
- Histone h2a (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 7xct
Q-score: 0.514
Ai H, Sun M, Liu A, Sun Z, Liu T, Cao L, Liang L, Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H, Zhao S, Li JB, Lou Z, Liu L
Nat Chem Biol (2022) 18 pp. 972-980 [ Pubmed: 35739357 DOI: doi:10.1038/s41589-022-01067-7 ]
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Dna (145-mer) (44 kDa, DNA from synthetic construct)
- Histone-lysine n-methyltransferase, h3 lysine-79 specific (37 kDa, Protein from Homo sapiens)
- Complex of dot1l(1-416) and h2bk34ub 2:1 nucleosome (Complex from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone domain-containing protein (11 kDa, Protein from Homo sapiens)
- Histone h4 (10 kDa, Protein from Homo sapiens)
- Dna (145-mer) (44 kDa, DNA from synthetic construct)
- Histone h2a (11 kDa, Protein from Homo sapiens)
cryo-EM map of Dot1L and H2BK34ub-H3K79Nle nucleosome complex containing addition map (1:1)
cryo-EM structure of H2BK34ub nucleosome
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7xd0
Q-score: 0.457
Ai H, Sun M, Liu A, Sun Z, Liu T, Cao L, Liang L, Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H, Zhao S, Li JB, Lou Z, Liu L
Nat Chem Biol (2022) 18 pp. 972-980 [ Pubmed: 35739357 DOI: doi:10.1038/s41589-022-01067-7 ]
- Dna (146-mer) (44 kDa, DNA from synthetic construct)
- H2bk34ub nucleosome (Complex from Homo sapiens)
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Ubiquitin-60s ribosomal protein l40 (8 kDa, Protein from synthetic construct)
- Histone h2b type 1-k (10 kDa, Protein from synthetic construct)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Histone domain-containing protein (11 kDa, Protein from Homo sapiens)
- Histone h2a (11 kDa, Protein from Homo sapiens)
cryo-EM structure of unmodified nucleosome
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xd1
Q-score: 0.558
Ai H, Sun M, Liu A, Sun Z, Liu T, Cao L, Liang L, Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H, Zhao S, Li JB, Lou Z, Liu L
Nat Chem Biol (2022) 18 pp. 972-980 [ Pubmed: 35739357 DOI: doi:10.1038/s41589-022-01067-7 ]
- Unmodified nucleosome (Complex from Homo sapiens)
- Histone h2a type 1-b/e (11 kDa, Protein from Homo sapiens)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Histone h3 (11 kDa, Protein from Homo sapiens)
- Dna (147-mer) (45 kDa, DNA from synthetic construct)
- Dna (147-mer) (45 kDa, DNA from synthetic construct)