Cryo-EM structure of human CMKLR1-Gi complex bound to chemerin
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8zjg
Q-score: 0.486
Commun Biol (2024) 7 pp. 1598-1598 [ DOI: doi:10.1038/s42003-024-07228-9 Pubmed: 39616240 ]
- Chemerin-like receptor 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Retinoic acid receptor responder protein 2 chemerinv (15 kDa, Protein from Homo sapiens)
- Human chemerin receptor 1-gi complex bound to chemerin (Complex from Homo sapiens)
Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8jei
Q-score: 0.535
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 5c-hcar3-gi complex (Complex from Homo sapiens)
- 3-nitro-4-(propylamino)benzoic acid (224 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of SUCR1 in complex with succinate and Gi protein
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8wog
Q-score: 0.556
Cell Rep (2024) 43 pp. 114381-114381 [ DOI: doi:10.1016/j.celrep.2024.114381 Pubmed: 38923454 ]
- Cryo-em structure of sucr1 in complex with succinate and gi protein (Complex from Homo sapiens)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Succinate receptor 1 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of SUCR1 in complex with cis-epoxysuccinic acid and Gi proteins
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8wp1
Q-score: 0.555
Cell Rep (2024) 43 pp. 114381-114381 [ DOI: doi:10.1016/j.celrep.2024.114381 Pubmed: 38923454 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cryo-em structure of sucr1 in complex with cis-epoxysuccinic acid and gi proteins (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- (2r,3s)-oxirane-2,3-dicarboxylic acid (132 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Succinate receptor 1 (35 kDa, Protein from Homo sapiens)
To Be Published
- Chemerin-like receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Retinoic acid receptor responder protein 2 (1 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Gpr1-c9-gi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8k4o
Q-score: 0.536
Liu A, Liu Y, Llinas Del Torrent Masachs C, Zhang W, Pardo L, Ye RD
PNAS (2024) 121 pp. e2403217121-e2403217121 [ Pubmed: 39378089 DOI: doi:10.1073/pnas.2403217121 ]
- G protein-coupled receptor (37 kDa, Protein from Human gammaherpesvirus 8)
- Guanine nucleotide-binding protein subunit gamma (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (39 kDa, Protein from Homo sapiens)
- Kaposi's sarcoma-associated herpesvirus-g protein-coupled receptor (kshv-gpcr)in complex with cxc chemokine cxcl1 and gi protein (Complex from Homo sapiens)
- Growth-regulated alpha protein (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (36 kDa, Protein from Homo sapiens)
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8k4p
Q-score: 0.555
Liu A, Liu Y, Llinas Del Torrent Masachs C, Zhang W, Pardo L, Ye RD
PNAS (2024) 121 pp. e2403217121-e2403217121 [ Pubmed: 39378089 DOI: doi:10.1073/pnas.2403217121 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- An active kaposi's sarcoma-associated herpesvirus-g protein-coupled receptor (kshv-gpcr) in complex with gi protein (Complex from Human gammaherpesvirus 8)
- G protein-coupled receptor (33 kDa, Protein from Human gammaherpesvirus 8)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of CXCR4 in complex with CXCL12
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8k3z
Q-score: 0.593
Liu Y, Liu A, Li X, Liao Q, Zhang W, Zhu L, Ye RD
Cell Rep (2024) 43 pp. 114578-114578 [ DOI: doi:10.1016/j.celrep.2024.114578 Pubmed: 39093700 ]
- C-x-c chemokine receptor type 4 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Cxcr4-cxcl12-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of NADPH oxidase 2 in complex with p22phox and EROS
Liang S, Liu A, Liu Y, Wang F, Zhou Y, Long Y, Wang T, Liu Z, Ren R, Ye RD
PNAS (2024) 121 pp. e2320388121-e2320388121 [ DOI: doi:10.1073/pnas.2320388121 Pubmed: 38805284 ]
- Cytochrome b-245 light chain (14 kDa, Protein from Homo sapiens)
- Nadph oxidase 2 in complex with cytochrome b-245 light chain, cytochrome b-245 chaperone 1 and a monoclonal antibody (Complex from Homo sapiens)
- Cytochrome b-245 heavy chain (64 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Monoclonal antibody 7g5 light chain (23 kDa, Protein from Oryctolagus cuniculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Monoclonal antibody 7g5 heavy chain (23 kDa, Protein from Oryctolagus cuniculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cytochrome b-245 chaperone 1 (18 kDa, Protein from Homo sapiens)