Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8jei
Q-score: 0.535
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Cryo-em structure of the compound 5c-hcar3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 3-nitro-4-(propylamino)benzoic acid (224 Da, Ligand)
Cryo-EM structure of CXCR4 in complex with CXCL12
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8k3z
Q-score: 0.593
Liu Y, Liu A, Li X, Liao Q, Zhang W, Zhu L, Ye RD
Cell Rep (2024) 43 pp. 114578-114578 [ Pubmed: 39093700 DOI: doi:10.1016/j.celrep.2024.114578 ]
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- Cxcr4-cxcl12-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (33 kDa, Protein from Homo sapiens)
CXCR3-DNGi complex activated by CXCL11
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hnk
Q-score: 0.532
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Cxcr3-cxcl11-dngi-scfv16 (Complex from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C-x-c motif chemokine 11 (11 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
CXCR3-DNGi complex activated by PS372424
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8hnl
Q-score: 0.548
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- (3s)-n-[(2s)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1h-isoquinoline-3-carboxamide (588 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- Cxcr3-ps372424-dngi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
CXCR3-DNGi complex activated by VUF11222
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8hnm
Q-score: 0.546
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Cxcr3-vuf11222-dngi-scfv16 (Complex from Homo sapiens)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- [4-(2-bromophenyl)phenyl]methyl-[[(1r,5s)-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl]-dimethyl-azanium (425 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Structure of CXCR3 complexed with antagonist SCH546738
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8hnn
Q-score: 0.434
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- 3-azanyl-6-chloranyl-5-[(3s)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide (492 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,kappa-type opioid receptor (56 kDa, Protein from Homo sapiens)
- Nb6 (18 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Cxcr3-kor-sch546738-nb6 (Complex from Homo sapiens)
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7ykd
Q-score: 0.549
Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD
PNAS (2023) 120 pp. e2214324120-e2214324120 [ DOI: doi:10.1073/pnas.2214324120 Pubmed: 36881626 ]
- Scfv16 (Complex)
- Chemerin-like receptor 1, guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Retinoic acid receptor responder protein 2 (1 kDa, Protein from Homo sapiens)
- Retinoic acid receptor responder protein 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemerin-like receptor 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cmklr1-gi -scfv16 complex (150 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 7xcr
Q-score: 0.571
Ai H, Sun M, Liu A, Sun Z, Liu T, Cao L, Liang L, Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H, Zhao S, Li JB, Lou Z, Liu L
Nat Chem Biol (2022) 18 pp. 972-980 [ Pubmed: 35739357 DOI: doi:10.1038/s41589-022-01067-7 ]
- Histone h4 (10 kDa, Protein from Homo sapiens)
- Histone h2a (11 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase, h3 lysine-79 specific (37 kDa, Protein from Homo sapiens)
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Complex of dot1l(1-416) and h2bk34ub nucleosome (Complex from Homo sapiens)
- Dna (146-mer) (44 kDa, DNA from synthetic construct)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Histone domain-containing protein (11 kDa, Protein from synthetic construct)
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 7xct
Q-score: 0.514
Ai H, Sun M, Liu A, Sun Z, Liu T, Cao L, Liang L, Qu Q, Li Z, Deng Z, Tong Z, Chu G, Tian X, Deng H, Zhao S, Li JB, Lou Z, Liu L
Nat Chem Biol (2022) 18 pp. 972-980 [ Pubmed: 35739357 DOI: doi:10.1038/s41589-022-01067-7 ]
- Dna (145-mer) (44 kDa, DNA from synthetic construct)
- Histone h2a (11 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase, h3 lysine-79 specific (37 kDa, Protein from Homo sapiens)
- Dna (145-mer) (44 kDa, DNA from synthetic construct)
- Complex of dot1l(1-416) and h2bk34ub 2:1 nucleosome (Complex from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Histone domain-containing protein (11 kDa, Protein from Homo sapiens)
- Histone h4 (10 kDa, Protein from Homo sapiens)