Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8jei
Q-score: 0.535
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 3-nitro-4-(propylamino)benzoic acid (224 Da, Ligand)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 5c-hcar3-gi complex (Complex from Homo sapiens)
Liu A, Liu Y, Chen G, Lyu W, Ye F, Wang J, Liao Q, Zhu L, Du Y, Ye RD
PLoS Biol (2024) 22 pp. e3002838-e3002838 [ DOI: doi:10.1371/journal.pbio.3002838 Pubmed: 39466725 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Chemerin-like receptor 2 (34 kDa, Protein from Homo sapiens)
- Retinoic acid receptor responder protein 2 (1 kDa, Protein from Homo sapiens)
- Gpr1-c9-gi-scfv16 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of human GPR1 bound to chemerin
Liu A, Liu Y, Chen G, Lyu W, Ye F, Wang J, Liao Q, Zhu L, Du Y, Ye RD
PLoS Biol (2024) 22 pp. e3002838-e3002838 [ DOI: doi:10.1371/journal.pbio.3002838 Pubmed: 39466725 ]
- G-protein coupled receptor 1 (35 kDa, Protein from Homo sapiens)
- Human gpr1 in complex with chemerin and heterotrimeric gi proteins (Complex from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (6 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Retinoic acid receptor responder protein 2 (15 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of CXCR4 in complex with CXCL12
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8k3z
Q-score: 0.593
Liu Y, Liu A, Li X, Liao Q, Zhang W, Zhu L, Ye RD
Cell Rep (2024) 43 pp. 114578-114578 [ DOI: doi:10.1016/j.celrep.2024.114578 Pubmed: 39093700 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cxcr4-cxcl12-gi-scfv16 complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (33 kDa, Protein from Homo sapiens)
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7ykd
Q-score: 0.549
Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD
PNAS (2023) 120 pp. e2214324120-e2214324120 [ DOI: doi:10.1073/pnas.2214324120 Pubmed: 36881626 ]
- Chemerin-like receptor 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Cmklr1-gi -scfv16 complex (150 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Chemerin-like receptor 1, guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Vicugna pacos)
- Cholesterol (386 Da, Ligand)
- Retinoic acid receptor responder protein 2 (1 kDa, Protein from Homo sapiens)
- Retinoic acid receptor responder protein 2 (Complex from Homo sapiens)