3-Methylcrotonyl-CoA Carboxylase in MCCD state with Acetyl CoA
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state with MCoA
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8jxm
Q-score: 0.289
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jxn
Q-score: 0.382
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of MPXV B6 and D68 fab complex
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8xs3
Q-score: 0.424
Zhao R, Wu L, Sun J, Liu D, Han P, Gao Y, Zhang Y, Xu Y, Qu X, Wang H, Chai Y, Chen Z, Gao GF, Wang Q
Nat Commun (2024) 15 pp. 4660-4660 [ Pubmed: 38821921 DOI: doi:10.1038/s41467-024-48312-2 ]
- D68_heavy chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein opg190 (28 kDa, Protein from Monkeypox virus)
- Structure of mpxv b6 complexed with d68 fab (Complex from Homo sapiens)
- D68_light chain (24 kDa, Protein from Homo sapiens)
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8jaw
Q-score: 0.506
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Dodecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j7d
Q-score: 0.435
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Human mcc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8j4z
Q-score: 0.418
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Heterododecamer of human mcc (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
Senktide bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jbf
Q-score: 0.524
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ DOI: doi:10.1038/s41421-023-00564-w Pubmed: 37391393 ]
- Guanine nucleotide-binding protein gq subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 nanobody (32 kDa, Protein from Mus musculoides)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Senktide (915 Da, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Neuromedin-k receptor (44 kDa, Protein from Homo sapiens)
- Senktide bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jbg
Q-score: 0.569
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ DOI: doi:10.1038/s41421-023-00564-w Pubmed: 37391393 ]
- Scfv16 nanobody (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein gq (g324) (41 kDa, Protein from Homo sapiens)
- Neuromedin-k receptor (nk3r-pfastbac1) (158 kDa, Protein from Homo sapiens)
- Neurokinin-b (1 kDa, Protein from Homo sapiens)
- Neurokinin b bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)