Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7w9k
Q-score: 0.507
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- Water (18 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7w9l
Q-score: 0.414
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w9m
Q-score: 0.437
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w9p
Q-score: 0.456
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w9t
Q-score: 0.431
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Human nav1.7 in complex with beta1, beta2 and huwentoxin (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
The cryo-EM structure of coxsackievirus A16 mature virion
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 6lha
Q-score: 0.504
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N
Cell Host Microbe (2020) 27 pp. 249- [ Pubmed: 32027857 DOI: doi:10.1016/j.chom.2020.01.003 ]
- Coxsackievirus a16 (Virus from Coxsackievirus A16)
- Vp4 protein (7 kDa, Protein from Coxsackievirus A16)
- Sphingosine (299 Da, Ligand)
- Vp3 protein (26 kDa, Protein from Coxsackievirus A16)
- Vp2 protein (27 kDa, Protein from Coxsackievirus A16)
- Vp1 protein (33 kDa, Protein from Coxsackievirus A16)
The cryo-EM structure of coxsackievirus A16 A-particle
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 6lhb
Q-score: 0.528
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N
Cell Host Microbe (2020) 27 pp. 249- [ Pubmed: 32027857 DOI: doi:10.1016/j.chom.2020.01.003 ]
- Vp2 (27 kDa, Protein from Coxsackievirus A16)
- Vp3 (26 kDa, Protein from Coxsackievirus A16)
- Vp1 (33 kDa, Protein from Coxsackievirus A16)
- Coxsackievirus a16 (Virus from Coxsackievirus A16)
The cryo-EM structure of coxsackievirus A16 empty particle
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 6lhc
Q-score: 0.517
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N
Cell Host Microbe (2020) 27 pp. 249- [ Pubmed: 32027857 DOI: doi:10.1016/j.chom.2020.01.003 ]
- Vp2 (27 kDa, Protein from Coxsackievirus A16)
- Vp3 (26 kDa, Protein from Coxsackievirus A16)
- Vp1 (33 kDa, Protein from Coxsackievirus A16)
- Coxsackievirus a16 (Virus from Coxsackievirus A16)
The cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab 18A7
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 6lhk
Q-score: 0.634
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N
Cell Host Microbe (2020) 27 pp. 249- [ Pubmed: 32027857 DOI: doi:10.1016/j.chom.2020.01.003 ]
- Coxsackievirus a16 (Virus from Coxsackievirus A16)
- Vp4 protein (7 kDa, Protein from Coxsackievirus A16)
- Sphingosine (299 Da, Ligand)
- Vp3 protein (26 kDa, Protein from Coxsackievirus A16)
- Vp2 protein (27 kDa, Protein from Coxsackievirus A16)
- Vp1 protein (33 kDa, Protein from Coxsackievirus A16)
The cryo-EM structure of coxsackievirus A16 A-particle in complex with Fab 18A7
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 6lhl
Q-score: 0.566
He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N
Cell Host Microbe (2020) 27 pp. 249- [ Pubmed: 32027857 DOI: doi:10.1016/j.chom.2020.01.003 ]
- Vp3 protein (26 kDa, Protein from Coxsackievirus A16)
- Vp2 protein (27 kDa, Protein from Coxsackievirus A16)
- Coxsackievirus a16 (Virus from Coxsackievirus A16)
- Vp1 protein (33 kDa, Protein from Coxsackievirus A16)