Senktide bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jbf
Q-score: 0.524
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ Pubmed: 37391393 DOI: doi:10.1038/s41421-023-00564-w ]
- Senktide bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein gq subunit alpha (41 kDa, Protein from Homo sapiens)
- Neuromedin-k receptor (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 nanobody (32 kDa, Protein from Mus musculoides)
- Senktide (915 Da, Protein from Homo sapiens)
Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jbg
Q-score: 0.569
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ Pubmed: 37391393 DOI: doi:10.1038/s41421-023-00564-w ]
- Neuromedin-k receptor (nk3r-pfastbac1) (158 kDa, Protein from Homo sapiens)
- Neurokinin b bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Neurokinin-b (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein gq (g324) (41 kDa, Protein from Homo sapiens)
- Scfv16 nanobody (32 kDa, Protein from Mus musculus)
Substance P bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jbh
Q-score: 0.575
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ Pubmed: 37391393 DOI: doi:10.1038/s41421-023-00564-w ]
- Substance p bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 nanobody (32 kDa, Protein from Mus musculoides)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Nk3r-pfastbac1 (158 kDa, Protein from Homo sapiens)
- Peptide from protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq subunit alpha (g324) (41 kDa, Protein from Homo sapiens)
Monomeric kinesin-1 motor domain in no-nucleotide state bound to GMPCPP-stabilized microtubule
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 6ojq
Q-score: 0.442
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Monomeric kinesin-1 motor domain in the no-nucleotide state bound to gmpcpp-stabilized microtubules (Complex from Bos taurus)
- Kinesin-1 heavy chain (35 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha-1b chain (48 kDa, Protein from Bos taurus)
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published
Cha HK, Debs G, Liu X, Liu D, Sindelar CV
To Be Published