Cryo-EM structure of opioid receptor with biased agonist
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8y45
Q-score: 0.407
Cheng L, Miao Z, Liu S, Li Z, Fu H, Xu C, Hu S, Zhao C, Liu Y, Zhao T, Liu W, Wang H, Liu R, Yan W, Tang X, Liu J, Shao Z, Ke B
Nat Commun (2024) 15 pp. 8284-8284 [ DOI: doi:10.1038/s41467-024-52601-1 Pubmed: 39333070 ]
- Delta-type opioid receptor (36 kDa, Protein from Homo sapiens)
- Cryo-em structure of opioid receptor with biased agonist (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- ~{n},~{n}-diethyl-4-(5-oxidanylspiro[chromene-2,4'-piperidine]-4-yl)benzamide (392 Da, Ligand)
Spike Trimer of BA.2.86 in complex with one hACE2
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8whs
Q-score: 0.272
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ Pubmed: 39071099 DOI: doi:10.1093/nsr/nwae206 ]
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 (Virus from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Spike Trimer of BA.2.86 in complex with two hACE2s
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8whu
Q-score: 0.261
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ Pubmed: 39071099 DOI: doi:10.1093/nsr/nwae206 ]
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Severe acute respiratory syndrome coronavirus 2 (Virus from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Spike Trimer of BA.2.86 with three RBDs down
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8whv
Q-score: 0.452
Spike Trimer of BA.2.86 with single RBD up
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 8whw
Q-score: 0.359
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8x4h
Q-score: 0.389
SARS-CoV-2 BA.2.75 Spike with K356T mutation (3 RBD down)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8x5q
Q-score: 0.427
SARS-CoV-2 BA.2.75 Spike with K356T mutation (1 RBD up)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8x5r
Q-score: 0.341
BA.2.86 Spike Trimer in complex with heparan sulfate
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 8xur
Q-score: 0.247
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ Pubmed: 39071099 DOI: doi:10.1093/nsr/nwae206 ]
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba.2.86 spike trimer in complex with heparan sulfate (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-o-sulfo-beta-l-altropyranuronic acid (274 Da, Ligand)
JN.1 Spike Trimer in complex with heparan sulfate
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8xus
Q-score: 0.372
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ Pubmed: 39071099 DOI: doi:10.1093/nsr/nwae206 ]
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Jn.1 spike trimer in complex with heparan sulfate (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-o-sulfo-beta-l-altropyranuronic acid (274 Da, Ligand)