The structure of ASFV DNA polymerase in apo state
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ywg
Q-score: 0.37
Kuai L, Sun J, Peng Q, Zhao X, Yuan B, Liu S, Bi Y, Shi Y
Nucleic Acids Res (2024) 52 pp. 10717-10729 [ Pubmed: 39189451 DOI: doi:10.1093/nar/gkae739 ]
- Dna polymerase (139 kDa, Protein from African swine fever virus)
- The asfv dna polymerase (Complex from African swine fever virus)
The structure of ASFV DNA polymerase in replicating state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ywi
Q-score: 0.508
Kuai L, Sun J, Peng Q, Zhao X, Yuan B, Liu S, Bi Y, Shi Y
Nucleic Acids Res (2024) 52 pp. 10717-10729 [ Pubmed: 39189451 DOI: doi:10.1093/nar/gkae739 ]
- The primer strand (7 kDa, DNA from African swine fever virus)
- Dna polymerase (139 kDa, Protein from African swine fever virus)
- Thymidine-5'-triphosphate (482 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- The template strand (11 kDa, DNA from African swine fever virus)
- The asfv dna polymerase in replicating state (Complex from African swine fever virus)
The structure of ASFV DNA polymerase in editing state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ywm
Q-score: 0.346
Kuai L, Sun J, Peng Q, Zhao X, Yuan B, Liu S, Bi Y, Shi Y
Nucleic Acids Res (2024) 52 pp. 10717-10729 [ Pubmed: 39189451 DOI: doi:10.1093/nar/gkae739 ]
- Dna polymerase (139 kDa, Protein from African swine fever virus)
- The template strand (8 kDa, DNA from African swine fever virus)
- The asfv dna polymerase in editing state (Complex from African swine fever virus)
- The primer strand (6 kDa, DNA from African swine fever virus)
Cryo-EM structure of USP1-UAF1-Ubiquitin in complex with TNG348
Simoneau A, Pratt CB, Wu HJ, Rajeswaran SS, Comer CG, Sudsakorn S, Zhang W, Liu S, Meier SR, Choi AH, Khendu T, Stowe H, Shen B, Whittington DA, Chen Y, Yu Y, Mallender WD, Feng T, Andersen JN, Maxwell JP, Throner S
Mol.Cancer Ther. (2025) [ DOI: doi:10.1158/1535-7163.MCT-24-0515 Pubmed: 39886906 ]
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- 2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-9-({4-[1-methyl-4-(trifluoromethyl)-1h-imidazol-2-yl]phenyl}methyl)-7-(2,2,2-trifluoroethyl)-7,9-dihydro-8h-purin-8-imine (603 Da, Ligand)
- Usp1-uaf1-ub complex with tng348 (174 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ubiquitin carboxyl-terminal hydrolase 1 (88 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 48 (77 kDa, Protein from Homo sapiens)
- 3-(methanesulfonyl)propan-1-amine (137 Da, Ligand)
Cryo-EM structure of human dimeric APJR-Gi complex with apelin-13.
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8xqe
Q-score: 0.304
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Dimeric apjr-gi complex with apelin-13 (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein subunit alpha i1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13.
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8xqf
Q-score: 0.405
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein subunit alpha i1 (40 kDa, Protein from Homo sapiens)
- Monomeric apjr-gi complex with apelin-13 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dimeric Apelin receptor.
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8xqi
Q-score: 0.454
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Homodimer of apelin receptor (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dimeric APJR complex with antagonistic antibody
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8xqj
Q-score: 0.444
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Jn241 (17 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of APJR complex with agonistic antibody
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8z74
Q-score: 0.394
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of APJR-Gi complex with agonistic antibody
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8z7j
Q-score: 0.388
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Apjr complexed with gi (Complex from Homo sapiens)