Extracellular domain of apo GC-A, state 1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bcl
Q-score: 0.59
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Extracellular domain of apo GC-A, state 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bcn
Q-score: 0.595
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Intracellular domain of apo GC-A
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bco
Q-score: 0.344
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Kinase homology domain of apo GC-A
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcp
Q-score: 0.398
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
Extracellular domain of GC-A bound to ANP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcq
Q-score: 0.599
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Intracellular domain of GC-A bound to ANP
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bcs
Q-score: 0.359
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cyclase domain of GC-A bound to ANP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9bcv
Q-score: 0.564
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fab fragment (10 kDa, Protein from Mus musculus)
- Atrial natriuretic peptide receptor 1 (115 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7jjo
Q-score: 0.599
Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY
Mol Cell (2020) 80 pp. 59- [ DOI: doi:10.1016/j.molcel.2020.08.001 Pubmed: 32818430 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric gs protein (160 kDa, Complex)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Isoprenaline (211 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Beta1-adrenergic receptor (Complex from Meleagris gallopavo)
- Nanobody 35 (Complex from Lama glama)
- Beta1-adrenergic receptor (57 kDa, Protein from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)