Extracellular domain of apo GC-A, state 1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bcl
Q-score: 0.59
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Extracellular domain of apo GC-A, state 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bcn
Q-score: 0.595
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Intracellular domain of apo GC-A
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bco
Q-score: 0.344
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Kinase homology domain of apo GC-A
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcp
Q-score: 0.398
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Extracellular domain of GC-A bound to ANP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcq
Q-score: 0.599
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
Intracellular domain of GC-A bound to ANP
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bcs
Q-score: 0.359
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Cyclase domain of GC-A bound to ANP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9bcv
Q-score: 0.564
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Magnesium ion (24 Da, Ligand)
- Atrial natriuretic peptide receptor 1 (115 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Fab fragment (10 kDa, Protein from Mus musculus)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7jjo
Q-score: 0.599
Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY
Mol Cell (2020) 80 pp. 59- [ DOI: doi:10.1016/j.molcel.2020.08.001 Pubmed: 32818430 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- Beta1-adrenergic receptor (57 kDa, Protein from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric gs protein (160 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Beta1-adrenergic receptor (Complex from Meleagris gallopavo)
- Isoprenaline (211 Da, Ligand)