Cryo-EM structure of human NADK tetramer
To Be Published
- Tetrameric cytoplasm nadk (200 kDa, Cellular component from Homo sapiens)
- Nad kinase (49 kDa, Protein from Homo sapiens)
Cryo-EM structure of human ABCC4
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8xok
Q-score: 0.438
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Apo human abcc4 (149 kDa, Cellular component from Homo sapiens)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
Cryo-EM structure of human ABCC4 with ANP bound in NBD1
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8xol
Q-score: 0.385
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Palmitic acid (256 Da, Ligand)
- Human abcc4 in complex with anp-bound in nbd1 (149 kDa, Cellular component from Homo sapiens)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8xom
Q-score: 0.365
Zhu Y, Xing X, Wang F, Chen L, Zhong C, Lu X, Yu Z, Yang Y, Yao Y, Song Q, Han S, Liu Z, Zhang P
FEBS Lett (2024) 598 pp. 1967-1980 [ Pubmed: 38886124 DOI: doi:10.1002/1873-3468.14955 ]
- Human abcc4 in complex with anp-bound in nbd1 and mtx (149 kDa, Cellular component from Homo sapiens)
- Methotrexate (454 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Cryo-EM structure of DltB homo-tetramer
Nat Commun (2024) 15 pp. 3404-3404 [ DOI: doi:10.1038/s41467-024-47783-7 Pubmed: 38649359 ]
- Teichoic acid d-alanyltransferase (51 kDa, Protein from Streptococcus thermophilus LMG 18311)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Apo dltb tetramer in ddm. (48 MDa, Cellular component from Streptococcus thermophilus)
- Diacyl glycerol (625 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
Cryo-EM structure of tetrameric DltB/DltC complex
Nat Commun (2024) 15 pp. 3404-3404 [ DOI: doi:10.1038/s41467-024-47783-7 Pubmed: 38649359 ]
- Teichoic acid d-alanyltransferase (51 kDa, Protein from Streptococcus thermophilus LMG 18311)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Tetrameric dltb/dltc complex in ddm. (8 MDa, Cellular component from Streptococcus thermophilus)
- Diacyl glycerol (625 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- D-alanyl carrier protein (8 kDa, Protein from Streptococcus thermophilus LMG 18311)
DltB tetramer in complex with inhibitor m-AMSA
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8jem
Q-score: 0.502
Nat Commun (2024) 15 pp. 3404-3404 [ DOI: doi:10.1038/s41467-024-47783-7 Pubmed: 38649359 ]
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Teichoic acid d-alanyltransferase (51 kDa, Protein from Streptococcus thermophilus LMG 18311)
- N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide (393 Da, Ligand)
- Dltb tetramer in complex with inhibitor m-amsa. (48 MDa, Complex from Streptococcus thermophilus)
- Diacyl glycerol (625 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)