SARS-CoV-2 Spike NTD in complex with neutralizing Fab SARS2-57 (local refinement)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7sww
Q-score: 0.328
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Whitener B, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DH
To Be Published
- Sars2-57 fv heavy chain (12 kDa, Protein from Mus musculus)
- Spike protein s1 (33 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-57 fv light chain (12 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-57 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-57 (three down conformation)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7swx
Q-score: 0.446
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Whitener B, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DH
To Be Published
- Sars2-57 fv heavy chain (12 kDa, Protein from Mus musculus)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-57 fv light chain (12 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-57 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 spike in complex with Multivalent miniprotein inhibitor FUS231-P24 (2RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor fus231-p24 (Protein from Synthetic construct)
- Sars-cov-2 spike in complex with multivalent minibinder fus231-p24 (2rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hexapro spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus231-p24 (Complex from Synthetic construct)
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS231-P24 (3RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Sars-cov-2 spike in complex with multivalent miniprotein inhibitor fus231-p24 (3rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus231-p24 (Protein from Synthetic construct)
- Sars-cov-2 hexapro spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus231-p24 (Complex from Synthetic construct)
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS31-G10 (2RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor fus31-g10 (Protein from Synthetic construct)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus31-g10 (Complex from Synthetic construct)
- Sars-cov-2 spike in complex with multivalent miniprotein inhibitor fus31-g10 (2rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS31-G10 (3RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor fus31-g10 (Protein from Synthetic construct)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with multivalent miniprotein inhibitor fus31-g10 (3rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus31-g10 (Complex from Synthetic construct)
SARS-CoV-2 spike in complex with AHB2-2GS-SB175 (local refinement of the RBD and AHB2)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7uhb
Q-score: 0.366
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (17 kDa, Protein from synthetic construct)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with ahb2-2gs-sb175 (local refinement of the rbd and ahb2) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ahb2-2gs-sb175 (Complex from Synthetic construct)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus)
SARS-CoV-2 spike in complex with AHB2-2GS-SB175
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uhc
Q-score: 0.465
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (17 kDa, Protein from synthetic construct)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (Complex from Synthetic construct)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with multivalent minibinder ahb2-2gs-sb175 (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Spike in complex with neutralizing Fab 2B04 (one up, two down conformation)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7k9h
Q-score: 0.455
Errico JM, Zhao H, Chen RE, Liu Z, Case JB, Ma M, Schmitz AJ, Rau MJ, Fitzpatrick JAJ, Shi PY, Diamond MS, Whelan SPJ, Ellebedy AH, Fremont DH
Cell Rep (2021) 37 pp. 109881-109881 [ DOI: doi:10.1016/j.celrep.2021.109881 Pubmed: 34655519 ]
- 2b04 heavy chain (13 kDa, Protein from Mus musculus)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab fragment of neutralizing monoclonal antibody 2b04 (Complex from Homo sapiens)
- Complex of sars-cov-2 spike with fab fragments of neutralizing antibody 2b04 (Complex)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2b04 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike RBD in complex with neutralizing Fab 2B04 (local refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k9i
Q-score: 0.476
Errico JM, Zhao H, Chen RE, Liu Z, Case JB, Ma M, Schmitz AJ, Rau MJ, Fitzpatrick JAJ, Shi PY, Diamond MS, Whelan SPJ, Ellebedy AH, Fremont DH
Cell Rep (2021) 37 pp. 109881-109881 [ DOI: doi:10.1016/j.celrep.2021.109881 Pubmed: 34655519 ]
- 2b04 heavy chain (13 kDa, Protein from Mus musculus)
- Complex of sars-cov-2 spike with fab fragment of monoclonal antibody 2b04 (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2b04 light chain (11 kDa, Protein from Mus musculus)
- Fab fragment of monoclonal antibody 2b04 (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)