CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jgb
Q-score: 0.551
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Conorfamide-tx2 (2 kDa, Protein from Conus textile)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8jgf
Q-score: 0.486
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq (41 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jgg
Q-score: 0.54
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (36 kDa, Protein from Homo sapiens)
- Cryoem structure of gi-coupled mrgprx1 with peptide agonist bam8-22 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of ATP13A2 in the E1-ATP state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8iek
Q-score: 0.377
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun (2023) 14 pp. 1978-1978 [ Pubmed: 37031211 DOI: doi:10.1038/s41467-023-37741-0 ]
- Cryo-em structure of atp13a2 in the e1-atp state (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Polyamine-transporting atpase 13a2 (128 kDa, Protein from Homo sapiens)
Cryo-EM structure of ATP13A2 in the E1-like state
Resolution: 5.65 Å
EM Method: Single-particle
Fitted PDBs: 8iel
Q-score: 0.229
Cryo-EM structure of ATP13A2 in the E2P state
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8iem
Q-score: 0.262
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun (2023) 14 pp. 1978-1978 [ Pubmed: 37031211 DOI: doi:10.1038/s41467-023-37741-0 ]
- Polyamine-transporting atpase 13a2 (123 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Beryllium trifluoride ion (66 Da, Ligand)
- Polyamine-transporting atpase 13a2 (Complex from Homo sapiens)
Cryo-EM structure of ATP13A2 in the E2-Pi state
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ien
Q-score: -0.047
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun (2023) 14 pp. 1978-1978 [ Pubmed: 37031211 DOI: doi:10.1038/s41467-023-37741-0 ]
- Polyamine-transporting atpase 13a2 (128 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cryo-em structure of atp13a2 in the e2-pi state (Complex from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)
Cryo-EM structure of ATP13A2 in the nominal E1P state
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8ieo
Q-score: 0.312
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun (2023) 14 pp. 1978-1978 [ Pubmed: 37031211 DOI: doi:10.1038/s41467-023-37741-0 ]
- Cryo-em structure of atp13a2 in the nominal e1p state (Complex from Homo sapiens)
- Polyamine-transporting atpase 13a2 (128 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
Cryo-EM structure of ATP13A2 in the putative of E2 state
Resolution: 4.87 Å
EM Method: Single-particle
Fitted PDBs: 8ier
Q-score: 0.162
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun (2023) 14 pp. 1978-1978 [ Pubmed: 37031211 DOI: doi:10.1038/s41467-023-37741-0 ]
- Spermine (202 Da, Ligand)
- Polyamine-transporting atpase 13a2 (128 kDa, Protein from Homo sapiens)
- Cryo-em structure of atp13a2 in the putative of e2 state (Complex from Homo sapiens)
Cryo-EM structure of ATP13A2 in the E1P-ADP state
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8ies
Q-score: 0.308
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun (2023) 14 pp. 1978-1978 [ Pubmed: 37031211 DOI: doi:10.1038/s41467-023-37741-0 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cryo-em structure of atp13a2 in the e1p-adp state (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Polyamine-transporting atpase 13a2 (125 kDa, Protein from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)