Cryo-EM structure of the receptor of xGPR4-Gs complex in pH6.2
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8zf4
Q-score: 0.497
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xGPR4-Gs complex in pH6.7
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8zf7
Q-score: 0.495
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8zfb
Q-score: 0.433
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9asd
Q-score: 0.506
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ Pubmed: 39383863 DOI: doi:10.1016/j.cell.2024.09.026 ]
- Vir-7229 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba 2.86 rbd - s2v29 complex (local refinement) (Complex from Sarbecovirus)
- Spike glycoprotein (141 kDa, Protein from Homo sapiens)
- Vir-7229 fab light chain (11 kDa, Protein from Homo sapiens)
VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9au2
Q-score: 0.499
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ Pubmed: 39383863 DOI: doi:10.1016/j.cell.2024.09.026 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vir-7229 fab light chain (23 kDa, Protein from Homo sapiens)
- Vir-7229 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand from Severe acute respiratory syndrome coronavirus 2)
- Ba.2.86 spike glycoprotein in complex with vir-7229 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of EBV gH/gL-gp42 in complex with fab 2C1
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8khr
Q-score: 0.465
Zhao GX, Fang XY, Bu GL, Chen SJ, Sun C, Li T, Xie C, Wang Y, Li SX, Meng N, Feng GK, Zhong Q, Kong XW, Liu Z, Zeng MS
Cell Rep Med (2024) 5 pp. 101573-101573 [ Pubmed: 38776874 DOI: doi:10.1016/j.xcrm.2024.101573 ]
- Soluble gp42 (22 kDa, Protein from Epstein-Barr virus (strain GD1))
- Envelope glycoprotein h (72 kDa, Protein from Epstein-Barr virus (strain GD1))
- Pentamer complex of gh/gl-gp42 with fab 2c1 (Complex from Epstein-Barr virus (strain GD1))
- 2c1 heavy chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein l (11 kDa, Protein from Epstein-Barr virus (strain GD1))
- 2c1 light chain (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of human receptor with G proteins
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ikg
Q-score: 0.432
Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z
PNAS (2024) 121 pp. e2321532121-e2321532121 [ Pubmed: 38830102 DOI: doi:10.1073/pnas.2321532121 ]
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- 3-[(1s)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1h-indole (332 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cb02-bound cb1r in complex with gi heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 (35 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of human receptor with G proteins
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ikh
Q-score: 0.431
Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z
PNAS (2024) 121 pp. e2321532121-e2321532121 [ Pubmed: 38830102 DOI: doi:10.1073/pnas.2321532121 ]
- Cannabinoid receptor 1 (Complex from Homo sapiens)
- 3-[(1r)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1h-indole (372 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cannabinoid receptor 1 (35 kDa, Protein from Homo sapiens)
- Cb05-bound cb1r in complex with gi heterotrimer (Complex)
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jgg
Q-score: 0.54
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (36 kDa, Protein from Homo sapiens)
- Cryoem structure of gi-coupled mrgprx1 with peptide agonist bam8-22 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
SARS-CoV-2 Delta variant spike protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8hrj
Q-score: 0.156