Electron Microscopy Data Bank

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Cryo-EM structure of the hE46K cross-seeded hWT alpha-synuclein fibril

Release date: May 5, 2021
Resolution: 3.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7c1d
Q-score: 0.463

Long H, Zheng W, Liu Y, Sun Y, Zhao K, Liu Z, Xia W, Lv S, Liu Z, Li D, He KW, Liu C

PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2012435118 Pubmed: 33972418 ]

Sample:

Alpha-synuclein (14 kDa, Protein from Homo sapiens)
The he46k cross-seeded hwt alpha-synuclein fibril (Cellular component from Homo sapiens)

EMD-0801

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Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril

Release date: Aug. 12, 2020
Resolution: 3.22 Å
EM Method: Helical reconstruction
Fitted PDBs: 6l1t
Q-score: 0.547

Zhao K, Lim YJ, Liu Z, Long H, Sun Y, Hu JJ, Zhao C, Tao Y, Zhang X, Li D, Li YM, Liu C

PNAS (2020) 117 pp. 20305-20315 [ Pubmed: 32737160 DOI: doi:10.1073/pnas.1922741117 ]

Sample:

Phosphorylated tyr39 a-synuclein amyloid fibril (Cellular component from Homo sapiens)
Alpha-synuclein (14 kDa, Protein from Homo sapiens)

EMD-0803

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Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril

Release date: Aug. 12, 2020
Resolution: 3.37 Å
EM Method: Helical reconstruction
Fitted PDBs: 6l1u
Q-score: 0.524

Zhao K, Lim YJ, Liu Z, Long H, Sun Y, Hu JJ, Zhao C, Tao Y, Zhang X, Li D, Li YM, Liu C

PNAS (2020) 117 pp. 20305-20315 [ Pubmed: 32737160 DOI: doi:10.1073/pnas.1922741117 ]

Sample:

Phosphorylated tyr39 a-synuclein amyloid fibril (Cellular component from Homo sapiens)
Alpha-synuclein (14 kDa, Protein from Homo sapiens)

EMD-0833

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cryo-em structure of alpha-synuclein fiber mutation type E46K

Release date: April 29, 2020
Resolution: 3.37 Å
EM Method: Helical reconstruction
Fitted PDBs: 6l4s
Q-score: 0.482

Zhao K, Li Y, Liu Z, Long H, Zhao C, Luo F, Sun Y, Tao Y, Su XD, Li D, Li X, Liu C

Nat Commun (2020) 11 pp. 2643-2643 [ DOI: doi:10.1038/s41467-020-16386-3 Pubmed: 32457390 ]

Sample:

Alpha-synuclein (5 kDa, Protein from Homo sapiens)
Alpha-synuclein fiber mutation type e46k (Complex from Homo sapiens)

EMD-0958

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Cryo-EM structure of A53T alpha-synuclein amyloid fibril

Release date: April 8, 2020
Resolution: 3.49 Å
EM Method: Helical reconstruction
Fitted PDBs: 6lrq
Q-score: 0.463

Sun Y, Hou S, Zhao K, Long H, Liu Z, Gao J, Zhang Y, Su XD, Li D, Liu C

Cell Res (2020) 30 pp. 360-362 [ Pubmed: 32203130 DOI: doi:10.1038/s41422-020-0299-4 ]

Sample:

A53t alpha-synuclein amyloid fibril (Cellular component from Homo sapiens)
Alpha-synuclein (14 kDa, Protein from Homo sapiens)

EMD-6988

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cryo-em structure of alpha-synuclein fiber

Release date: July 11, 2018
Resolution: 3.07 Å
EM Method: Helical reconstruction
Fitted PDBs: 6a6b
Q-score: 0.455

Li Y, Zhao C, Luo F, Liu Z, Gui X, Luo Z, Zhang X, Li D, Liu C, Li X

Cell Res (2018) 28 pp. 897-903 [ DOI: doi:10.1038/s41422-018-0075-x Pubmed: 30065316 ]

Sample:

Alpha-synuclein (6 kDa, Protein from Homo sapiens)
Alpha-synuclein fiber (Complex from Homo sapiens)

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